ArticleAnnals of neurology2022
ApoB and Non-HDL Cholesterol Versus LDL Cholesterol for Ischemic Stroke Risk.
Article in Annals of neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Associations between lipoproteins and risk of ischemic stroke: a systematic review and meta-analysis of Mendelian randomization studies.Frontiers in neurology · 2025Pooled it
- Integrative biochemical and computational analysis identifies LOX-1 and IL-6R as therapeutic targets in oxidative, inflammatory and lipid dysregulation of ischemic stroke.Pakistan journal of medical sciences · 2026Article
- Lipid metabolism, microglia, and stroke.Neural regeneration research · 2026Article
- Joint association of triglyceride-glucose index and atherogenic lipid markers with incident stroke risk.Scientific reports · 2026Article
- Importance and Management of Non-High-Density Lipoprotein Cholesterol in Dyslipidemia Treatment.JACC. Asia · 2026Review
- Diagnostic and Severity Assessment of Coronary Artery Disease Using ApoB/ApoA-I Ratio: Insights from a Statin-Treated Eastern European Cohort.Medicina (Kaunas, Lithuania) · 2026Article
- Analysis of the correlation between the serum residual cholesterol level at admission and the risk of death after discharge in patients with ischemic stroke.Journal of medical biochemistry · 2026Article
- The inflammatory marker SIRI acts as a statistical mediator between ApoB/ApoA1 ratio and atrial fibrillation, and combined biomarkers show higher discriminative ability for the presence of atrial fibrillation than single indicators.Frontiers in cardiovascular medicine · 2026Article
- Combined Impact of Mean and Variability of Non-HDL Cholesterol on Myocardial Infarction in Hemodialysis Patients.Journal of clinical medicine · 2025Article
- Joint analysis of atherogenic index of plasma clusters and a body shape index trajectories in incident stroke risk.Lipids in health and disease · 2025Article
- Association of Lipid Profile With Cardiovascular Diseases and All-Cause Death: A 2-Decade Follow-Up of the Tehran Lipid and Glucose Study.Journal of the American Heart Association · 2025Article
- Quantitative proteomic analysis of the protective effect exerted by alliin on ox-LDL-injured HUVECs.Scientific reports · 2025Article
- Study on risk factors and associated drug related problems in patients with stroke.BMC neurology · 2025Article
- Correlation of sdLDL-C and Apob with the degree of cerebral artery stenosis in posterior circulation stroke.Scientific reports · 2025Article
- Non-HDL-C, Symptomatic Intracranial Arterial Stenosis, and Recurrent Vascular Risk in Minor Stroke.Journal of atherosclerosis and thrombosis · 2025Article
- Evaluation of the effect of statin treatment on intracranial atherosclerotic plaques using magnetic resonance vessel wall imaging: a case series.Frontiers in neurology · 2025Article
- Systematic analysis of the burden of ischemic stroke attributable to high LDL-C from 1990 to 2021.Frontiers in neurology · 2025Article
- U-shaped relationship between frailty and non-HDL-cholesterol in the elderly: a cross-sectional study.Frontiers in nutrition · 2025Article
- Insulin resistance as potential mediator linking ApoB/ApoA1 to MAFLD, but not inflammation.Therapeutic advances in endocrinology and metabolism · 2025Article
- Pleiotropic Effects of PCSK9 Inhibitors on Cardio-Cerebrovascular Diseases.Biomedicines · 2024Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveConflicting results have been reported on the association between lipids and risk of ischemic stroke. We tested the hypothesis that the burden of ischemic stroke attributable to either elevated apolipoprotein B (apoB) or non-high-density lipoprotein (non-HDL) cholesterol is higher than that attributable to elevated low-density lipoprotein (LDL) cholesterol.
methodsWe included 104,618 individuals from an ongoing cohort study, the Copenhagen General Population Study. The associations of quintiles of apoB, non-HDL cholesterol, and LDL cholesterol with risk of ischemic stroke were estimated by Cox proportional hazards regressions with 95% confidence intervals. With 1
resultsHigher quintiles of apoB and non-HDL cholesterol were associated with increased risk of ischemic stroke (both trends: p < 0.0001), whereas for LDL cholesterol this association was somewhat attenuated (trend: p = 0.0005). A similar pattern was seen for population attributable fraction values. Compared to individuals in the 1
interpretationThe proportion of ischemic stroke attributable to either elevated apoB or non-HDL cholesterol was double that attributable to elevated LDL cholesterol. ANN NEUROL 2022;92:379-389.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.