Evidence map›Paper›PMID 35634909›Full record

ArticlePharmaceutical biology2022

Flaxseed extract reduces tissue accumulation and enhances urinary excretion of chondroitin sulphate in the rat: a possible new path in substrate reduction therapy for mucopolysaccharidosis.

Sabir Es-Said, Karima Lafhal, Abdelaati Elkhiat, Miloud Hammoud, Noureddine Regbaoui, Aicha Ezoubeiri, Rachida Makbal, Safia Sbyea, Omar Elhiba, Souad Sellami and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceutical biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 1 country.

Sabir Es-SaidMetabolic Platform, Biochemistry Laboratory, Faculty of Medicine, Cadi Ayad, University, Marrakech, Morocco.
Karima LafhalMetabolic Platform, Biochemistry Laboratory, Faculty of Medicine, Cadi Ayad, University, Marrakech, Morocco.
Abdelaati ElkhiatNeurosciences, Pharmacology and Environment Unit (NPEU), Faculty of Sciences, Semlalia, Cadi Ayyad University, Marrakech, Morocco.
Miloud HammoudMetabolic Platform, Biochemistry Laboratory, Faculty of Medicine, Cadi Ayad, University, Marrakech, Morocco.
Noureddine RegbaouiDepartment of Biology; Faculty of Science Semlalia, Cadi Ayad University, Marrakesh, Morocco.
Aicha EzoubeiriClinical Laboratory; Ibn Tofail Hospital, Mohammed VI Hospital University, Marrakech, Morocco.
Rachida MakbalBiotechnology, Protection, and Development of Plant Resources Laboratory, Faculty of Sciences, Semlalia, Cadi Ayyad University, Marrakech, Morocco.
Safia SbyeaMetabolic Platform, Biochemistry Laboratory, Faculty of Medicine, Cadi Ayad, University, Marrakech, Morocco.
Omar ElhibaNutritional, Physiopathologies and Toxicology Team, Faculty of Sciences, Chouaib Doukkali University, El Jadida, Morocco.
Souad SellamiDepartment of Pathological Anatomy, Mohammed VI Hospital University, Marrakech, Morocco.
Hanane RaisDepartment of Pathological Anatomy, Mohammed VI Hospital University, Marrakech, Morocco.
Abdallah KarimLaboratory of Coordination Chemistry, Faculty of Sciences Semlalia, Cadi Ayad University, Marrakech, Morocco.ORCID 0000-0001-5389-1060
Halima GamraniNeurosciences, Pharmacology and Environment Unit (NPEU), Faculty of Sciences, Semlalia, Cadi Ayyad University, Marrakech, Morocco.
Noureddine RadaMother-Child Hospital, Pediatric Department, Mohammed VI University Hospital, Cadi Ayad University, Marrakesh, Morocco.
Mohammed BouskraouiMother-Child Hospital, Pediatric Department, Mohammed VI University Hospital, Cadi Ayad University, Marrakesh, Morocco.
Naima FdilMetabolic Platform, Biochemistry Laboratory, Faculty of Medicine, Cadi Ayad, University, Marrakech, Morocco.ORCID 0000-0003-3312-9778
Cadi Ayyad University · MACentre Hospitalier Universitaire Mohammed VI · MAChouaib Doukkali University · MA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

contextChondroitin 6 sulphate (C6S) is a glycosaminoglycan (GAG) whose accumulation is notable in mucopolysaccharidosis type IVA and VII. Flaxseed,

objectiveWe assess the effect of total ethanol flaxseed extract (EFSE) in an animal model of C6S accumulation. MATERIALS AND

methodsThe study was performed in adult male Wistar rats (

resultsDry EFSE contains total phenols (6.28 mg EAG/g), condensed tannins (2.98 mg ECAT/g) and flavonoids (0.44 mg ECAT/g) with high antioxidant potential [RPE (IC DISCUSSION AND

conclusionsEFSE showed significant potential for chelation. Its use for the treatment of GAG accumulation could be suggested and generalized to a larger study population.

Indexed as

FlaxMucopolysaccharidosesAnimalsAntioxidantsChondroitin SulfatesGlycosaminoglycansHumansMalePlant ExtractsRatsRats, WistarAntioxidantsChondroitin SulfatesGlycosaminoglycansPlant ExtractsAntioxidant activitychelating effectchondroitin 6-sulphategenisteinlignansquercetin

Identifiers

PMID35634909
PMCPMC9477488
OpenAlexW4282044886

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.