ArticlePlant biotechnology journal2022
The upregulated LsKN1 gene transforms pinnately to palmately lobed leaves through auxin, gibberellin, and leaf dorsiventrality pathways in lettuce.
Article in Plant biotechnology journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 28 citations in OpenAlex.
- KNOX1 Transcription Factors in Plants with a Special Focus on Horticultural Crops: A Review.Plants (Basel, Switzerland) · 2026Review
- Article
- Dissecting the genetic architecture of key agronomic traits in lettuce using a MAGIC population.Genome biology · 2025Article
- Unraveling the multifaceted roles of SPL transcription factors in leaf development.Frontiers in plant science · 2025Review
- Leaf form diversity and evolution: a never-ending story in plant biology.Journal of plant research · 2024Review
- Identification of Chromosomal Regions and Candidate Genes forPlants (Basel, Switzerland) · 2024Article
- Rewiring of a KNOXI regulatory network mediated by UFO underlies the compound leaf development in Medicago truncatula.Nature communications · 2024Article
- Exogenously applied gibberellic acid and benzylamine modulate growth and chemical constituents of dwarf schefflera: a stepwise regression analysis.Scientific reports · 2024Article
- Differentially methylated genomic regions of lettuce seeds relate to divergence across morphologically distinct horticultural types.AoB PLANTS · 2023Article
- The Roles of Gibberellins in Regulating Leaf Development.Plants (Basel, Switzerland) · 2023Review
- Combined analysis of the transcriptome and metabolome provides insights into the fleshy stem expansion mechanism in stem lettuce.Frontiers in plant science · 2022Article
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Leaf shape represents a vital agronomic trait for leafy vegetables such as lettuce. Some lettuce cultivars produce lobed leaves, varying from pinnately to palmately lobed, but the genetic mechanisms remain unclear. In this study, we cloned one major quantitative trait locus (QTL) controlling palmately lobed leaves. The candidate gene, LsKN1, encodes a homeobox transcription factor, and has been shown previously to be critical for the development of leafy heads in lettuce. The LsKN1 allele that is upregulated by the insertion of a transposon promotes the development of palmately lobed leaves. We demonstrated that LsKN1 upregulated LsCUC2 and LsCUC3 through different mechanisms, and their upregulation was critical for the development of palmately lobed leaves. LsKN1 binds the promoter of LsPID to promote auxin biosynthesis, which positively contributes to the development of palmately lobed leaves. In contrast, LsKN1 suppresses GA biosynthesis to promote palmately lobed leaves. LsKN1 also binds to the promoter of LsAS1, a dorsiventrality gene, to downregulate its expression. Overexpression of the LsAS1 gene compromised the effects of the LsKN1 gene changing palmately to pinnately lobed leaves. Our study illustrated that the upregulated LsKN1 gene led to palmately lobed leaves in lettuce by integrating several downstream pathways, including auxin, gibberellin, and leaf dorsiventrality pathways.
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