ArticleFrontiers in endocrinology2022
Associations of Lumber Disc Degeneration With Paraspinal Muscles Myosteatosis in Discogenic Low Back Pain.
Article in Frontiers in endocrinology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Structural changes of the multifidus in animal models of intervertebral disk degeneration: a systematic review.Frontiers in surgery · 2024Pooled it
- The Association Between Lumbar Disc Degeneration and Paraspinal Muscle Morphology: The Role of Age in a Quantitative Magnetic Resonance Imaging-Based Study.Biomedicines · 2026Article
- Magnetic Resonance Imaging Segmentation of Soft Tissue in the Diagnosis of Chronic Low Back Pain: A Scoping Review.Diagnostics (Basel, Switzerland) · 2026Review
- Quantitative MRI assessment of paraspinal muscles and the psoas: associations with low back pain.Quantitative imaging in medicine and surgery · 2026Article
- Association between lumbar disc degeneration at L4-L5 level and atrophy of paraspinal muscles and gluteus medius: a cross-sectional study using 3T quantitative magnetic resonance imaging.BMC medical imaging · 2025Article
- What a pain in the back: etiology, diagnosis and future treatment directions for discogenic low back pain.Bone research · 2025Review
- Association Between Sarcopenia and the Long-Term Risk of Intervertebral Disc Degeneration.Journal of cachexia, sarcopenia and muscle · 2025Article
- Assessment of muscle fiber types transformation in rats with discogenic low back pain using diffusion tensor image of paraspinal muscles.BMC medical imaging · 2025Article
- Article
- Editorial: Women in science: musculoskeletal pain.Frontiers in pain research (Lausanne, Switzerland) · 2025Article
- Animal Models of Intervertebral Disc Diseases: Advantages, Limitations, and Future Directions.Neurology international · 2024Review
- Role of effective atomic number of paraspinal muscles in the prediction of acute vertebral fracture risk assessment: a cross-sectional case-control study.The British journal of radiology · 2024Article
- Association of MRI findings with paraspinal muscles fat infiltration at lower lumbar levels in patients with chronic low back pain: a multicenter prospective study.BMC musculoskeletal disorders · 2024Article
- Article
- Role of End Plate Changes and Paraspinal Muscle Pathology in Lower Back Pain: A Narrative Review.Cureus · 2024Review
- Review
- Advances in the interaction between lumbar intervertebral disc degeneration and fat infiltration of paraspinal muscles: critical summarization, classification, and perspectives.Frontiers in endocrinology · 2024Review
- The effect of lumbar multifidus muscle degeneration on upper lumbar disc herniation.Frontiers in surgery · 2024Article
- Multifidus dysfunction and restorative neurostimulation: a scoping review.Pain medicine (Malden, Mass.) · 2023Article
- Correlation between inflammatory cytokine expression in paraspinal tissues and severity of disc degeneration in individuals with lumbar disc herniation.BMC musculoskeletal disorders · 2023Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Accompanied with intervertebral disc (IVD) degeneration, increasing fat infiltration of paraspinal muscles may be related to discogenic low back pain (DLBP), but their relationship is still unclear and the classical animal models are not completely applicable. The purpose of this study was to assess the paraspinal muscle fat infiltration in patients with DLBP by quantitative MRI, and to develop a novel DLBP rat model to explore the potential relationship between DLBP paraspinal muscle fat infiltration and TNF-α levels. We measured the proton density fat fraction (PDFF) of the multifidus and erector spinae muscles of 70 DLBP patients and 36 healthy volunteers by using quantitative MRI IDEAL-IQ. In addition, we developed a DLBP experimental rat model by puncturing the L4/5 and L5/6 IVDs under the guidance of X-ray fluoroscopy. Then various behavioral experiments, MRI and pathological examination of IVDs were used to evaluate the performance of the DLBP animal model. The gait analysis, hot plate test, acetone test, grasping test and tail suspension test were used to evaluate the pain and muscle dysfunction in rats. Through quantitative MRI and histological examination, the degeneration of IVDs and fat infiltration in the muscles were observed
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