Evidence map›Paper›PMID 35634340›Full record

ReviewFrontiers in immunology2022

The Potential Role of Gut Microbial-Derived Exosomes in Metabolic-Associated Fatty Liver Disease: Implications for Treatment.

Binbin Zhang, Jianan Zhao, Minjie Jiang, Dandan Peng, Xiaobing Dou, Yu Song, Junping Shi

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  13. Clinical, cosmetic and investigational dermatology · 2025
    Article
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  17. Exosomes fromInternational journal of molecular sciences · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Binbin ZhangDepartment of Translational Medicine Platform, The Affiliated Hospital of Hangzhou Normal University, Hangzhou, China.
Jianan ZhaoGuanghua Clinical Medical College, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Minjie JiangZhejiang University of Traditional Chinese Medicine, Hangzhou, China.
Dandan PengDepartment of Translational Medicine Platform, The Affiliated Hospital of Hangzhou Normal University, Hangzhou, China.
Xiaobing DouZhejiang University of Traditional Chinese Medicine, Hangzhou, China.
Yu SongZhejiang University of Traditional Chinese Medicine, Hangzhou, China.
Junping ShiDepartment of Translational Medicine Platform, The Affiliated Hospital of Hangzhou Normal University, Hangzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The prevalence and incidence of metabolic-associated fatty liver disease (MAFLD), a clinically heterogeneous disease whose primary clinical therapies include dietary control and exercise therapy, is increasing worldwide and constitutes a significant medical burden. Gut microbes influence the physiopathological processes of the liver through different mechanisms based on the gut-liver axis. Exosomes are essential carriers of intercellular communication. Most previous studies have focused on adipocyte- and hepatocyte-derived exosomes, while the critical role of microbial-derived exosomes and the molecular mechanisms behind them in MAFLD have received little attention. Therefore, we searched and screened the latest relevant studies in the

Indexed as

ExosomesGastrointestinal MicrobiomeNon-alcoholic Fatty Liver DiseaseHumansLiver Cirrhosisgut microbial-derived exosomesinflammatory responseinsulin resistanceintestinal barrierlipid metabolismliver fibrosismetabolic-associated fatty liver diseasetherapeutic approaches

Identifiers

PMID35634340
PMCPMC9131825

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.