Evidence map›Paper›PMID 35634326›Full record

ArticleFrontiers in immunology2022

Oxygen Desaturation Is Associated With Fibrocyte Activation

Chun-Hua Wang, Chun-Yu Lo, Hung-Yu Huang, Tsai-Yu Wang, Chih-Ming Weng, Chih-Jung Chen, Yu-Chen Huang, Fu-Tsai Chung, Chang-Wei Lin, Kian Fan Chung and 1 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.1field-weighted citation impact, top 62% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Circulating Fibrocytes: Cellular Mediators of Tissue Fibrosis.International journal of molecular sciences · 2026
    Review
  3. Article
  4. Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 2 countries.

Chun-Hua WangDepartment of Thoracic Medicine, Chang Gung Memorial Hospital, Taipei, Taiwan.
Chun-Yu LoDepartment of Thoracic Medicine, Chang Gung Memorial Hospital, Taipei, Taiwan.
Hung-Yu HuangDepartment of Thoracic Medicine, Chang Gung Memorial Hospital, Taipei, Taiwan.
Tsai-Yu WangDepartment of Thoracic Medicine, Chang Gung Memorial Hospital, Taipei, Taiwan.
Chih-Ming WengSchool of Respiratory Therapy, Taipei Medical University, Taipei, Taiwan.
Chih-Jung ChenDepartment of Pathology, Taichung Veterans General Hospital, Taichung, Taiwan.
Yu-Chen HuangDepartment of Thoracic Medicine, Chang Gung Memorial Hospital, Taipei, Taiwan.
Fu-Tsai ChungDepartment of Thoracic Medicine, Chang Gung Memorial Hospital, Taipei, Taiwan.
Chang-Wei LinDepartment of Thoracic Medicine, Chang Gung Memorial Hospital, Taipei, Taiwan.
Kian Fan ChungAirway Disease Section, National Heart and Lung Institute, Imperial College London, London, United Kingdom.
Han-Pin KuoDepartment of Thoracic Medicine, Taipei Medical University Hospital, Taipei, Taiwan.
Chang Gung Memorial Hospital · TWChang Gung University · TWChung Shan Medical University · TWImperial College London · GBTaipei Medical University · TWTaipei Medical University Hospital · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fibrocytes are bloodborne mesenchymal progenitors which accumulate and differentiate at the disease site. We investigated whether hypoxemia activates fibrocytes, accelerating airflow limitation and exercise intolerance in chronic obstructive pulmonary disease (COPD) patients. Flow cytometry was used to determine collagen I

Indexed as

Hypoxia-Inducible Factor 1, alpha SubunitPulmonary Disease, Chronic ObstructiveErbB ReceptorsHumansHypoxiaOxygenReceptors, CXCR4ErbB ReceptorsHypoxia-Inducible Factor 1, alpha SubunitOxygenReceptors, CXCR4chronic obstructive pulmonary disease (COPD)desaturationepidermal growth factor receptor (EGFR)fibrocytehypoxia-inducible factor-1α (HIF-1α)

Identifiers

PMID35634326
PMCPMC9134242
OpenAlexW4280630042

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.