Evidence map›Paper›PMID 35634274›Full record

ArticleFrontiers in immunology2022

Pemphigus Foliaceus Autoantibodies Induce Redistribution Primarily of Extradesmosomal Desmoglein 1 in the Cell Membrane.

Matthias Hiermaier, Daniela Kugelmann, Mariya Y Radeva, Dario Didona, Kamran Ghoreschi, Solimani Farzan, Michael Hertl, Jens Waschke

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Cortical tension regulates desmosomal morphogenesis.Frontiers in cell and developmental biology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Matthias HiermaierChair of Vegetative Anatomy, Institute of Anatomy, Faculty of Medicine, LMU Munich, München, Germany.
Daniela KugelmannChair of Vegetative Anatomy, Institute of Anatomy, Faculty of Medicine, LMU Munich, München, Germany.
Mariya Y RadevaChair of Vegetative Anatomy, Institute of Anatomy, Faculty of Medicine, LMU Munich, München, Germany.
Dario DidonaDepartment of Dermatology and Allergology, Philipps University, Marburg, Germany.
Kamran GhoreschiDepartment of Dermatology, Venereology and Allergology, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Solimani FarzanDepartment of Dermatology, Venereology and Allergology, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Michael HertlDepartment of Dermatology and Allergology, Philipps University, Marburg, Germany.
Jens WaschkeChair of Vegetative Anatomy, Institute of Anatomy, Faculty of Medicine, LMU Munich, München, Germany.
Charité - Universitätsmedizin Berlin · DELMU Klinikum · DELudwig-Maximilians-Universität München · DEPhilipps University of Marburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The autoimmune dermatosis pemphigus foliaceus (PF) is predominantly caused by IgG autoantibodies against the desmosomal cadherin desmoglein (Dsg) 1. The exact mechanisms that lead to the characteristic epidermal blistering are not yet fully understood. In the present study, we used a variety of biophysical methods to examine the fate of membrane-bound Dsg1 after incubation with PF patients' IgG. Dispase-based dissociation assays confirmed that PF-IgG used for this study reduced intercellular adhesion in a manner dependent on phospholipase C (PLC)/Ca

Indexed as

PemphigusAutoantibodiesCell MembraneDesmoglein 1HumansImmunoglobulin GAutoantibodiesDesmoglein 1Immunoglobulin Gdesmoglein (Dsg)localizationpemphigussignaling / signaling pathwaysStimulated Emission Depletion (STED)

Identifiers

PMID35634274
PMCPMC9134081
OpenAlexW4280533790

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.