Evidence map›Paper›PMID 35634245›Full record

ArticleOncotarget2022

NF-κB over-activation portends improved outcomes in HPV-associated head and neck cancer.

Travis P Schrank, Andrew C Prince, Tejas Sathe, Xiaowei Wang, Xinyi Liu, Damir T Alzhanov, Barbara Burtness, Albert S Baldwin, Wendell G Yarbrough, Natalia Issaeva

Open access · diamondAbstract read
In one paragraph

Article in Oncotarget, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Development of a Clinical Assay to Guide Patient Therapy in HPV-Associated Head and Neck Cancer.Clinical cancer research : an official journal of the American Association for Cancer Research · 2026
    Article
  5. Genomic Enrichment and Functional Impact of TP53 and CYLD Alterations in Recurrent and Metastatic HPV-Associated Head and Neck Cancer.Clinical cancer research : an official journal of the American Association for Cancer Research · 2026
    Article
  6. Review
  7. Review
  8. Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. Review
  16. Noncanonical HPV carcinogenesis drives radiosensitization of head and neck tumors.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  17. Article
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Travis P SchrankDepartment of Otolaryngology/Head and Neck Surgery, UNC, Chapel Hill, NC 27599, USA.
Andrew C PrinceDepartment of Otolaryngology/Head and Neck Surgery, UNC, Chapel Hill, NC 27599, USA.
Tejas SatheDepartment of Surgery, Otolaryngology, Yale, New Haven, CT 06519, USA.
Xiaowei WangDepartment of Pharmacology and Bioengineering, University of Illinois at Chicago, Chicago, IL 60612, USA.
Xinyi LiuDepartment of Pharmacology and Bioengineering, University of Illinois at Chicago, Chicago, IL 60612, USA.
Damir T AlzhanovDepartment of Otolaryngology/Head and Neck Surgery, UNC, Chapel Hill, NC 27599, USA.
Barbara BurtnessDepartment of Medicine, Yale School of Medicine, New Haven, CT 06510, USA.
Albert S BaldwinDepartment of Medicine, Yale School of Medicine, New Haven, CT 06510, USA.
Wendell G YarbroughDepartment of Otolaryngology/Head and Neck Surgery, UNC, Chapel Hill, NC 27599, USA.
Natalia IssaevaDepartment of Otolaryngology/Head and Neck Surgery, UNC, Chapel Hill, NC 27599, USA.
University of North Carolina Health Care · USUniversity of Illinois Chicago · USYale Cancer Center · USUniversity of North Carolina at Chapel Hill · USYale University · US

Funding

Yale Head and Neck Cancer SPORE: Overcoming Treatment Resistance in Head and Neck CancerP50DE030707 · NIDCR · YALE UNIVERSITY · PI DECKER, ROY · 2020 to 2024
$11.8M
Observational study to validate circulating HPVDNA and prognostic genomic biomarkers for diagnosis and treatment of HPV-associated OPSCCU01DE029754 · NIDCR · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ISSAEVA, NATALIA, YARBROUGH, WENDELL G · 2020 to 2024
$3.8M
Research Training in OtolaryngologyT32DC005360 · NIDCD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MANIS, PAUL B · 2003 to 2023
$2.8M
MICRORNA BIOMARKERS FOR OROPHARYNGEAL CANCERR01DE026471 · NIDCR · WASHINGTON UNIVERSITY · PI WANG, XIAOWEI · 2017 to 2021
$2.2M
Mechanisms Determining Dysregulation of the NRF2 Oxidative Stress Response in Head and Neck Squamous Cell CarcinomaK08DE029241 · NIDCR · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SCHRANK, TRAVIS P. · 2020 to 2024
$870k
NIDCD NIH HHS T32 DC005360NIDCR NIH HHS K08 DE029241NIDCR NIH HHS P50 DE030707NIDCR NIH HHS R01 DE026471NIDCR NIH HHS U01 DE029754
6 · The paper itself

Abstract

Evolving understanding of head and neck squamous cell carcinoma (HNSCC) is leading to more specific diagnostic disease classifications. Among HNSCC caused by the human papilloma virus (HPV), tumors harboring defects in

Indexed as

AlphapapillomavirusHead and Neck NeoplasmsPapillomavirus InfectionsDeubiquitinating Enzyme CYLDHumansNF-kappa BPapillomaviridaeSquamous Cell Carcinoma of Head and NeckTNF Receptor-Associated Factor 3Deubiquitinating Enzyme CYLDNF-kappa BTNF Receptor-Associated Factor 3CYLDhead and neck cancerHPVNF-κBTRAF3

Identifiers

PMID35634245
PMCPMC9131933
OpenAlexW4285743596

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.