Evidence map›Paper›PMID 35634195›Full record

ArticleLeukemia research reports2022

A rare case of B-lymphoid blast phase of chronic myeloid leukemia: Diagnostic challenges.

Nada Naiyer, Ann-Leslie Zaslav, Tahmeena Ahmed, Silvia Spitzer, Yupo Ma, Roxanna Ponce, Htien Lee, Hong Lin

Open access · goldAbstract readCase Reports
In one paragraph

Article in Leukemia research reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Nada NaiyerDepartment of Pathology, Stony Brook University School of Medicine, 101 Nicolls Road, Stony Brook, New York 11794-7300, United States.
Ann-Leslie ZaslavDepartment of Pathology, Stony Brook University School of Medicine, 101 Nicolls Road, Stony Brook, New York 11794-7300, United States.
Tahmeena AhmedDepartment of Pathology, Stony Brook University School of Medicine, 101 Nicolls Road, Stony Brook, New York 11794-7300, United States.
Silvia SpitzerDepartment of Pathology, Stony Brook University School of Medicine, 101 Nicolls Road, Stony Brook, New York 11794-7300, United States.
Yupo MaDepartment of Pathology, Stony Brook University School of Medicine, 101 Nicolls Road, Stony Brook, New York 11794-7300, United States.
Roxanna PonceDepartment of Pathology, Stony Brook University School of Medicine, 101 Nicolls Road, Stony Brook, New York 11794-7300, United States.
Htien LeeDepartment of Pathology, Stony Brook University School of Medicine, 101 Nicolls Road, Stony Brook, New York 11794-7300, United States.
Hong LinDepartment of Pathology, Stony Brook University School of Medicine, 101 Nicolls Road, Stony Brook, New York 11794-7300, United States.
Stony Brook University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic myeloid leukemia(CML) is characterized by Philadelphia(Ph) chromosome. About 5% of cases are diagnosed in blast phase. We report a case of a 53-year-old female with no significant medical history, in B-lymphoblast crisis. Flow cytometry demonstrated B-lymphoblasts with no myeloid aberrancies, together with immature neutrophils in blood, and B-lymphoblasts in bone marrow. Cytogenetic studies identified Ph+ with complex abnormalities. Molecular analysis showed positive both for p210 and p190 transcripts in blood. ABL1 mutation analysis by Next Generation Sequencing(NGS) detected Thr315Ile mutation, which confers resistance to many tyrosine kinase inhibitors(TKIs). Eight months later she received allogeneic transplant and is doing well.

Indexed as

Acute lymphoblastic leukemiaBCR-ABL1Chronic myeloid leukemiaCML blast phaseCytogeneticsFlow cytometry

Identifiers

PMID35634195
PMCPMC9133756
OpenAlexW4280502979

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.