ArticleWorld journal of gastroenterology2022
Clinical outcomes of endoscopic papillectomy of ampullary adenoma: A multi-center study.
Article in World journal of gastroenterology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06648746 (Predictors of Therapeutic Success and Adverse Events in Endoscopic Ampullectomy), which is not on this map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Predictors of Therapeutic Success and Adverse Events in Endoscopic Ampullectomy
Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.
- Therapeutic strategies and outcomes in the management of ampullary tumours: meta-analysis.BJS open · 2026Pooled it
- Forward- vs. Oblique-Viewing Endoscope for Duodenal Papillectomy: A Comparative Study on Efficacy and Safety.Digestive diseases and sciences · 2026Article
- Clinical Validation of a Generative AI System for Diagnosing Ampullary Lesions: A Multicenter Study.United European gastroenterology journal · 2026Article
- AI-powered hierarchical classification of ampullary neoplasms: a deep learning approach using white-light and narrow-band imaging.Surgical endoscopy · 2026Article
- Nationwide Survey on Endoscopic Papillectomy for Ampullary Adenoma: Current Practices and Variability.Gut and liver · 2026Article
- A sequential strategy of upfront radiofrequency ablation followed by endoscopic papillectomy for complex ampullary tumors.Frontiers in medicine · 2026Article
- Quality of life and outcomes in patients undergoing endoscopic papillectomyWorld journal of gastrointestinal surgery · 2025Article
- Balloon catheter-assisted endoscopic resection for papillary adenoma of non-exposed protruded type (with video).DEN open · 2025Article
- Article
- Risk factors for recurrence after endoscopic papillectomy in ampullary adenomas: a retrospective case-control study.Therapeutic advances in gastroenterology · 2025Article
- Pushing the Boundaries of Ampullectomy for Benign Ampullary Tumors: 25-Year Outcomes of Surgical Ampullary Resection Associated with Duodenectomy or Biliary Resection.Journal of clinical medicine · 2024Article
- The Significance of Histopathological Findings on Clinical Outcomes in Endoscopic Papillectomy with Endocut.Journal of clinical medicine · 2023Article
- Clinical outcomes: endoscopic resection of duodenal ampullary lesions.Translational gastroenterology and hepatology · 2023Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAmpullary adenoma is a rare premalignant lesion, but its incidence is increasing. Endoscopic papillectomy has become the first treatment of choice for ampullary adenomas due to its safety and effectiveness, thereby replacing surgical resection. However, recurrence rates and adverse events after endoscopic papillectomy were reported in up to 30% of cases.
aimTo review the long-term outcomes of endoscopic papillectomy and investigate the factors that affect these outcomes.
methodsWe retrospectively analyzed the data of patients who underwent endoscopic papillectomy for ampullary adenoma at five tertiary hospitals between 2013 and 2020. We evaluated clinical outcomes and their risk factors. The definitions of outcomes were as follow: (1) curative resection: complete endoscopic resection without recurrence; (2) endoscopic success: treatment of ampullary adenoma with endoscopy without surgical intervention; (3) early recurrence: reconfirmed adenoma at the first endoscopic surveillance; and (4) late recurrence: reconfirmed adenoma after the first endoscopic surveillance.
resultsA total of 106 patients were included for analysis. Of the included patients, 81 (76.4%) underwent curative resection, 99 (93.4%) had endoscopic success, showing that most patients with non-curative resection were successfully managed with endoscopy. Sixteen patients (15.1%) had piecemeal resection, 22 patients (20.8%) had shown positive/uncertain resection margin, 11 patients (16.1%) had an early recurrence, 13 patients (10.4%) had a late recurrence, and 6 patients (5.7%) had a re-recurrence. In multivariate analysis, a positive/uncertain margin [Odds ratio (OR) = 4.023,
conclusionEndoscopic papillectomy is a safe and effective treatment for ampullary adenomas. Careful selection and follow-up of patients is mandatory, particularly in cases with positive/uncertain margin and piecemeal resection.
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