SynthesisAsian Pacific journal of cancer prevention : APJCP2022
Diabetes History and Gastric Cancer Risk: Different Results by Types of Follow-Up Studies.
Synthesis in Asian Pacific journal of cancer prevention : APJCP, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
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Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Diabetes and gastric cancer incidence and mortality in the Asia Cohort Consortium: A pooled analysis of more than a half million participants.Journal of diabetes · 2024Pooled it
- Association between type 2 diabetes and gastric cancer in Europeans and East Asians based on two sample Mendelian randomization.Discover oncology · 2025Article
- α‑Fetoprotein‑positive hepatoid adenocarcinoma of the stomach and a new classification: A case report.Oncology letters · 2024Article
- Metabolic Conditions and Organ Dysfunctions Risk Factors for Gastrointestinal Cancer in Hypertensive Patients: A Case-Control Study in China.Cancer management and research · 2024Article
- Association between Dietary Inflammatory Index and Gastric Adenocarcinoma: A Multicenter Case-Control Study in Brazil.Nutrients · 2023Article
- Diabetes Mellitus and Gastric Cancer: Correlation and Potential Mechanisms.Journal of diabetes research · 2023Review
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Abstract
objectiveThe previous systematic reviews evaluating the association between diabetes history and gastric cancer risk showed inconsistent results. The aim was to check through a meta-epidemiological study that the conclusions of systematic reviews evaluating the association between diabetes history and gastric cancer risk might differ by the type of follow-up study.
methodsThe potential study subjects were follow-up studies selected from the seven systematic reviews obtained by searching PubMed using diabetes and gastric cancer keywords. The selection criterion was defined as a follow-up study for evaluating the association between the history of type 2 diabetes mellitus and the incidence of gastric cancer. And the values of RR and its 95%CI, which adjusted for the most confounders in each paper, were extracted for meta-analysis. A random-effects model meta-analysis by types of the follow-up study and sex group was performed.
resultsA total of 25 follow-up studies were finally selected for meta-analysis. They were classified into 16 retrospective and 9 prospective studies in types of follow-up study. The statistical significance between diabetes history and gastric cancer risk was found in retrospective studies (sRR=1.17, 95%CI: 1.02-1.34, I-squared =91.0%) but disappeared in prospective studies (sRR=1.09, 95%CI: 0.91-1.29, I-squared = 68.6%). Even in the analysis of subgroups by sex, statistical significance was not found in the prospective study, consistently.
conclusionThe main reason for the previous meta-analysis's diverse results for the association between diabetes history and gastric cancer risk was that the type of follow-up study was not reflected. According to the meta-analysis of prospective cohort studies, it could be concluded that there is no association between diabetes history and gastric cancer risk.
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