Evidence map›Paper›PMID 35633496›Full record

ArticleNeurology and therapy2022

Functional Specificity of TPS Brain Stimulation Effects in Patients with Alzheimer's Disease: A Follow-up fMRI Analysis.

Gregor Dörl, Eva Matt, Roland Beisteiner

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology and therapy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 3 pooled it
2.6field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 3 syntheses or guidelines pooled it, 31 citations in OpenAlex.

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  18. Ultrasound Neuromodulation as a New Brain Therapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Gregor DörlDepartment of Neurology, Medical University of Vienna, Spitalgasse 23, 1090, Vienna, Austria.
Eva MattDepartment of Neurology, Medical University of Vienna, Spitalgasse 23, 1090, Vienna, Austria.
Roland BeisteinerDepartment of Neurology, Medical University of Vienna, Spitalgasse 23, 1090, Vienna, Austria. roland.beisteiner@meduniwien.ac.at.
Medical University of Vienna · AT

Funding

Austrian Science Fund FWF KLIF455Medizinische Universität Wien SO10300020Universität Wien SO10300020
6 · The paper itself

Abstract

introductionTranscranial pulse stimulation (TPS) has been recently introduced as a novel clinical brain stimulation technique based on highly focused ultrasound pressure pulses. In a first pilot study on clinical effects of navigated and focused ultrasound neuromodulation, a dichotomy of functional effects was found: patients with Alzheimer's disease improved cognition and language but deteriorated with visuo-constructive functions.

methodsWe analyzed changes in functional connectivity measured with functional magnetic resonance imaging (fMRI) using graph analysis of a visuo-constructive network in 18 patients with Alzheimer's disease. We calculated the network's global efficiency and tested for correlation with visuo-constructive test scores to explain this dichotomy.

resultsImportant visuo-constructive network nodes were not stimulated in the pilot setting and correspondingly global efficiency of a visuo-constructive network was decreased after TPS therapy, compatible with a natural progress of the disease. A correlation between visuo-constructive scores and changes in global efficiency was found.

conclusionResults argue for a high functional specificity of ultrasound-based neuromodulation with TPS.

Indexed as

Alzheimer’s diseaseFunctional magnetic resonance imagingNon-invasive brain stimulationTranscranial pulse stimulationUltrasoundVisuo-construction

Identifiers

PMID35633496
PMCPMC9338196
OpenAlexW4281676772

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.