ArticleInterdisciplinary sciences, computational life sciences2022
EPI-Mind: Identifying Enhancer-Promoter Interactions Based on Transformer Mechanism.
Article in Interdisciplinary sciences, computational life sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed, 15 citations in OpenAlex.
- Class-balanced negative training sets for improving classifier model predictions of enhancer-promoter interactions.BMC bioinformatics · 2025Article
- RAEPI: Predicting Enhancer-Promoter Interactions Based on Restricted Attention Mechanism.Interdisciplinary sciences, computational life sciences · 2025Article
- DNA sequence analysis landscape: a comprehensive review of DNA sequence analysis task types, databases, datasets, word embedding methods, and language models.Frontiers in medicine · 2025Review
- EPI-DynFusion: enhancer-promoter interaction prediction model based on sequence features and dynamic fusion mechanisms.Frontiers in genetics · 2025Article
- EPI-Trans: an effective transformer-based deep learning model for enhancer promoter interaction prediction.BMC bioinformatics · 2024Article
- Computational methods for identifying enhancer-promoter interactions.Quantitative biology (Beijing, China) · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
motivationEnhancer-Promoter Interactions (EPIs) is an essential step in the gene regulation process. However, the detection of EPIs by traditional wet experimental techniques is time-consuming and expensive. Thus, computational methods would be very useful for understanding the mechanism of EPIs. A number of approaches have been proposed to address this problem. Nevertheless, there is room for exploration and improvement for the existing research methods.
methodsIn this study, a novel deep-learning model named EPI-Mind was proposed to predict EPIs with sequences features. First, we encoded enhancers and promoters sequences with pre-trained DNA vectors. Then, the Convolutional Neural Network (CNN) was utilized to rough extract the global and local features. Finally, the transformer mechanism was introduced to further extract the feature. We first trained a model named EPI-Mind_spe which can predict EPIs in one cell line. To achieve general prediction across different cell lines and further improve the performance of the model, a second-time training was carried on. The redivided dataset were used to train a new model called EPI-Mind_gen which can predict EPIs across different cell lines. To further improve the accuracy, a new model named EPI-Mind_best was trained which used the EPI-Mind_gen as a pre-trained model.
resultsEPI-Mind_spe has the ability of predict EPIs with average AUROC above 90% and average AUPR above 70% but with cell lines specificity. EPI-Mind_gen can predict EPIs across different cell lines and its average AUROC is higher than the EPI-Mind_spe about 4.8%. EPI-Mind_best is superior to the state-of-the-art predictors on benchmarking datasets. EPI-Mind_best achieved best in 5 indicators within 12 indicators consists of AUPR and AUROC which is better than pioneers.
conclusionThis research proposed a method, which was called EPI-Mind, to predict EPIs only with enhancer and promoters sequences, the framework of which was based on deep learning. This manuscript may provide a new route to solve the problem.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.