Evidence map›Paper›PMID 35633427›Full record

ArticleInternational ophthalmology2022

Correlating the patterns of diabetic macular edema, optical coherence tomography biomarkers and grade of diabetic retinopathy with stage of renal disease.

Manisha Agarwal, Mani Sachdeva, Shalin Shah, Rajiv Raman, Padmaja K Rani, Ramachandran Rajalakshmi, Sobha Sivaprasad, T P Vignesh, Kim Ramasamy, Aishwarya Madharia and 8 more

Abstract read
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In one paragraph

Article in International ophthalmology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 7 institutions in 2 countries.

Manisha AgarwalVitreoretina department, Dr. Shroff's Charity Eye Hospital, 5027, Kedarnath Lane, Daryaganj, New Delhi, 110002, India. agarwalmannii@yahoo.co.in.ORCID http://orcid.org/0000-0002-2277-001X
Mani SachdevaVitreoretina department, Dr. Shroff's Charity Eye Hospital, 5027, Kedarnath Lane, Daryaganj, New Delhi, 110002, India.ORCID http://orcid.org/0000-0001-6040-6692
Shalin ShahVitreoretina department, Dr. Shroff's Charity Eye Hospital, 5027, Kedarnath Lane, Daryaganj, New Delhi, 110002, India.ORCID http://orcid.org/0000-0002-7254-8249
Rajiv RamanVitreoretina Department, Sankara Nethralaya, 18 college road, Chennai, Tamil Nadu, 600 006, India.ORCID http://orcid.org/0000-0001-5842-0233
Padmaja K RaniVitreoretina Department, Smt Kanuri Santhamma Centre for Vitreoretinal Diseases, LV Prasad Eye Institute, Hyderabad, Telangana, 500045, India.ORCID http://orcid.org/0000-0001-7069-8238
Ramachandran RajalakshmiMedical Retina and Ocular Research, Department of Ophthalmology, Dr. Mohan's Diabetes Specialities Centre and Madras Diabetes Research Foundation, 6, Conran Smith Road, Gopalapuram, Chennai, Tamil Nadu, 600086, India.ORCID http://orcid.org/0000-0002-7063-6026
Sobha SivaprasadNIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust, London, UK.ORCID http://orcid.org/0000-0001-8952-0659
T P VigneshVitreoretina Department, Aravind Eye Hospital, 1,Annanagar, Madurai, Tamil Nadu, 625 020, India.ORCID http://orcid.org/0000-0003-0945-1994
Kim RamasamyVitreoretina Department, Aravind Eye Hospital, 1,Annanagar, Madurai, Tamil Nadu, 625 020, India.
Aishwarya MadhariaVitreoretina Department, Sadguru Netra Chikitsalya, Chitrakoot, 210204, India.
Alok SenVitreoretina Department, Sadguru Netra Chikitsalya, Chitrakoot, 210204, India.ORCID http://orcid.org/0000-0003-2374-4187
Shalini SugumarRetina Vitreous Service, Vitreoretina Department, LV Prasad Eye Institute, MTC Campus, Bhubaneswar, 751024, India.
Umesh Chandra BeheraRetina Vitreous Service, Vitreoretina Department, LV Prasad Eye Institute, MTC Campus, Bhubaneswar, 751024, India.
Ann Maria RodriguesVitreoretina Department, Giridhar Eye Institute, Near Ponneth Temple, Cochin, 682 020, India.
Giridhar AnantharamanVitreoretina Department, Giridhar Eye Institute, Near Ponneth Temple, Cochin, 682 020, India.
Swati PriyaVitreoretina Department, Sankara Nethralaya, 18 college road, Chennai, Tamil Nadu, 600 006, India.
Atanu MajumdarBio-statistical department, Dr. Shroff's Charity Eye Hospital, New Delhi, 110002, India.
India Retinal Disease Study group
Dr. Shroff’s Charity Eye Hospital · INL V Prasad Eye Institute · INAravind Eye Hospital · INChaithanya Eye Hospital and Research Institute · INSankara Nethralaya · INMadras Diabetes Research Foundation · INMoorfields Eye Hospital NHS Foundation Trust · GB

Funding

Medical Research Council MR/P027881/1Ornate India GCRF UKRI funding MR/P207881/1
6 · The paper itself

Abstract

purposeTo correlate optical coherence tomography (OCT)-based morphological patterns of diabetic macular edema (DME), biomarkers and grade of diabetic retinopathy (DR) in patients with various stages of chronic kidney disease (CKD) secondary to diabetes.

designMulticentric retrospective cross-sectional study was conducted at seven centers across India.

methodsData from medical records of patients with DME and CKD were entered in a common excel sheet across all seven centers. Staging of CKD was based on estimated glomerular filtration rate (eGFR).

resultsThe most common morphological pattern of DME was cystoid pattern (42%) followed by the mixed pattern (31%). The proportion of different morphological patterns did not significantly vary across various CKD stages (p = 0.836). The presence of external limiting membrane-ellipsoid zone (ELM-EZ) defects (p < 0.001) and foveal sub-field thickness (p = 0.024) showed a direct correlation with the stage of CKD which was statistically significant. The presence of hyperreflective dots (HRD) and disorganization of inner retinal layers (DRIL) showed no significant correlation with the stage of CKD. Sight threatening DR was found to increase from 70% in CKD stage 3 to 82% in stages 4 and 5 of CKD, and this was statistically significant (p = 0.03).

conclusionCystoid morphological pattern followed by mixed type was the most common pattern of DME on OCT found in patients suffering from stage 3 to 5 of CKD. However, the morphological patterns of DME did not significantly vary across various CKD stages. ELM-EZ defects may be considered as an important OCT biomarker for advanced stage of CKD.

Indexed as

Diabetes MellitusDiabetic RetinopathyMacular EdemaRenal Insufficiency, ChronicBiomarkersCross-Sectional StudiesHumansRetrospective StudiesTomography, Optical CoherenceBiomarkersCKDDMEeGFRMorphological patternOCT biomarkers

Identifiers

PMID35633427
OpenAlexW4281735801

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.