Evidence map›Paper›PMID 35633394›Full record

SynthesisEuropean archives of psychiatry and clinical neuroscience2022

Cognitive impairment in people with schizophrenia: an umbrella review.

Yohannes Gebreegziabhere, Kassahun Habatmu, Awoke Mihretu, Matteo Cella, Atalay Alem

Abstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in European archives of psychiatry and clinical neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 133 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
133citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

133 citing papers in PubMed, 5 syntheses or guidelines pooled it.

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  19. Are cognitive deficits more severe among people with treatment-resistant schizophrenia than treatment responders?Australasian psychiatry : bulletin of Royal Australian and New Zealand College of Psychiatrists · 2026
    Article
  20. Article

73 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yohannes GebreegziabhereDepartment of Nursing, College of Health Sciences, Debre Berhan University, Debre Berhan, Ethiopia. yohannes36@gmail.com.ORCID http://orcid.org/0000-0003-3649-9555
Kassahun HabatmuSchool of Psychology, College of Education and Behavioral Studies, Addis Ababa University, Addis Ababa, Ethiopia.
Awoke MihretuDepartment of Psychiatry, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia.
Matteo CellaDepartment of Psychology, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, England, UK.
Atalay AlemDepartment of Psychiatry, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia.

Funding

African Mental Health Research Initiative (AMARI) DEL-15-01Wellcome Trust
6 · The paper itself

Abstract

Cognitive impairment is one of the core symptoms of schizophrenia. Quite a number of systematic reviews were published related to cognitive impairment in people with schizophrenia (PWS). This umbrella review, therefore, aimed at reviewing and synthesizing the findings of systematic reviews related to domains of cognition impaired and associated factors in PWS. We searched four electronic databases. Data related to domains, occurrence, and associated factors of cognitive impairment in PWS were extracted. The quality of all eligible systematic reviews was assessed using A MeaSurement Tool to Assess methodological quality of systematic Review (AMSTAR) tool. Results are summarized and presented in a narrative form. We identified 63 systematic reviews fulfilling the eligibility criteria. The included reviews showed that PWS had lower cognitive functioning compared to both healthy controls and people with affective disorders. Similar findings were reported among psychotropic free cases and people with first episode psychosis. Greater impairment of cognition was reported in processing speed, verbal memory, and working memory domains. Greater cognitive impairment was reported to be associated with worse functionality and poor insight. Cognitive impairment was also reported to be associated with childhood trauma and aggressive behaviour. According to our quality assessment, the majority of the reviews had moderate quality. We were able to find a good number of systematic reviews on cognitive impairment in PWS. The reviews showed that PWS had higher impairment in different cognitive domains compared to healthy controls and people with affective disorders. Impairment in domains of memory and processing speed were reported frequently.

Indexed as

Cognitive DysfunctionPsychotic DisordersSchizophreniaCognitionHumansSystematic Reviews as TopicCognitive impairmentDeterminantsDomains impairedSchizophrenia

Identifiers

PMID35633394
PMCPMC9508017

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.