ArticleInternational journal of cancer2022
Racial disparities in epithelial ovarian cancer survival: An examination of contributing factors in the Ovarian Cancer in Women of African Ancestry consortium.
Article in International journal of cancer, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 19 citations in OpenAlex.
- Differences in overall survival for invasive epithelial ovarian cancer by race and ethnicity: results from the Ovarian Cancer Association Consortium.British journal of cancer · 2026Article
- A Multistate Survival Model to Identify Risk Factors for Lethal Ovarian Cancer.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2026Article
- Residential Context and Survival Disparities in Black and White Women With Ovarian Cancer.JAMA network open · 2026Observational
- Surgical Recommendations for Black Women Compared to White Women With Ovarian Cancer in the US.Cureus · 2026Article
- Racial and Ethnic Disparities in Diet-Related Cancer Risk Awareness and Behaviors Among Cancer Survivors: An Analysis of the Health Information National Trends Survey (HINTS).Journal of cancer education : the official journal of the American Association for Cancer Education · 2026Article
- Neighborhood disorder and ovarian cancer survival in Black women.American journal of epidemiology · 2025Article
- Perceived discrimination, trust in physicians, and their associations with ovarian cancer mortality among women in the African American Cancer Epidemiology Study.Cancer causes & control : CCC · 2025Article
- Trial Enrollment and Survival Disparities Among Patients With Advanced Epithelial Ovarian Carcinoma.JAMA network open · 2025Article
- The Power of Strategic Social Media Influencer Communication to Improve Black Women's Knowledge and Awareness of Environmental Endocrine-Disrupting Chemicals: Surveys of Instagram Users.Journal of medical Internet research · 2025Article
- Prognostic factor analysis and nomogram construction for elderly patients with stages III and IV epithelial ovarian cancer: a study based on the SEER database.Translational cancer research · 2025Article
- Elucidating the influences of social determinants of health on perceived overall health among African American/Black and Hispanic ovarian cancer survivors using the NIH All of Us Research Program.Gynecologic oncology · 2024Article
- Patient- and system-level factors associated with racial/ethnic disparities in the delivery of guideline-concordant therapy among US patients with gastric cancer.Journal of surgical oncology · 2024Article
- Article
- Racial and socioeconomic disparities in survival among women with advanced-stage ovarian cancer who received systemic therapy.Cancer causes & control : CCC · 2024Article
- Advances in artificial intelligence for the diagnosis and treatment of ovarian cancer (Review).Oncology reports · 2024Review
- Role of neighborhood context in ovarian cancer survival disparities: current research and future directions.American journal of obstetrics and gynecology · 2023Review
- Survival of epithelial ovarian cancer in Black women: a society to cell approach in the African American cancer epidemiology study (AACES).Cancer causes & control : CCC · 2023Article
- Disparities in Gynecologic Cancers.Cancer journal (Sudbury, Mass.)Review
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Authors and funding
18 authors at 13 institutions in 1 country.
Funding
Abstract
Black women diagnosed with epithelial ovarian cancer have poorer survival compared to white women. Factors that contribute to this disparity, aside from socioeconomic status and guideline-adherent treatment, have not yet been clearly identified. We examined data from the Ovarian Cancer in Women of African Ancestry (OCWAA) consortium which harmonized data on 1074 Black women and 3263 white women with ovarian cancer from seven US studies. We selected potential mediators and confounders by examining associations between each variable with race and survival. We then conducted a sequential mediation analysis using an imputation method to estimate total, direct, and indirect effects of race on ovarian cancer survival. Black women had worse survival than white women (HR = 1.30; 95% CI 1.16-1.47) during study follow-up; 67.9% of Black women and 69.8% of white women died. In our final model, mediators of this disparity include college education, nulliparity, smoking status, body mass index, diabetes, diabetes/race interaction, postmenopausal hormone (PMH) therapy duration, PMH duration/race interaction, PMH duration/age interaction, histotype, and stage. These mediators explained 48.8% (SE = 12.1%) of the overall disparity; histotype/stage and PMH duration accounted for the largest fraction. In summary, nearly half of the disparity in ovarian cancer survival between Black and white women in the OCWAA consortium is explained by education, lifestyle factors, diabetes, PMH use, and tumor characteristics. Our findings suggest that several potentially modifiable factors play a role. Further research to uncover additional mediators, incorporate data on social determinants of health, and identify potential avenues of intervention to reduce this disparity is urgently needed.
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