Evidence map›Paper›PMID 35633295›Full record

ArticleInternational wound journal2023

Lugol's solution and Gentian violet eradicate methicillin-resistant Staphylococcus aureus biofilm in skin wound infections.

Torstein Grønseth, Kirill V Ovchinnikov, Harald Carlsen, Jūratė Šaltytė Benth, Dzung B Diep, Magnus von Unge, Juha T Silvola

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International wound journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Torstein GrønsethInstitute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.ORCID https://orcid.org/0000-0002-9005-6483
Kirill V OvchinnikovFaculty of Chemistry, Biotechnology and Food Science, Norwegian University of Life Sciences, Ås, Norway.
Harald CarlsenFaculty of Chemistry, Biotechnology and Food Science, Norwegian University of Life Sciences, Ås, Norway.
Jūratė Šaltytė BenthInstitute of Clinical Medicine, Campus Ahus, University of Oslo, Oslo, Norway.
Dzung B DiepFaculty of Chemistry, Biotechnology and Food Science, Norwegian University of Life Sciences, Ås, Norway.
Magnus von UngeDepartment of Otolaryngology, Head and Neck Surgery, Akershus University Hospital, Nordbyhagen, Norway.
Juha T SilvolaInstitute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.
Norwegian University of Life Sciences · NOUniversity of Oslo · NOOslo University Hospital · NOUppsala University · SE

Funding

Universitetet i Oslo
6 · The paper itself

Abstract

The study aimed to evaluate the antibacterial efficacy of Lugol's solution 5% and Gentian violet 1% against methicillin-resistant Staphylococcus aureus (MRSA) biofilm in vivo. The bactericidal efficacy for treatment of MRSA-biofilm skin wound infection was tested in a murine model. Luciferase-tagged S. aureus Xen31, a MRSA-strain derived from S. aureus ATCC-3359130, was used for infection. Wounds were made in the skin of mice and infected with MRSA. The mice were treated with Lugol's solution and Gentian violet. Application of the antimicrobial agents started 24 hours post infection and was repeated daily for five-days. The antimicrobial effect on the biofilm bacteria was evaluated by measuring bioluminescence from MRSA daily for seven-days. Lugol's solution and Gentian violet showed a significant reduction in luminescent signals from the first assessment day to all subsequent days (P < .001). Lugol's solution and Gentian violet effectively eradicated MRSA in biofilm in vivo and could be alternatives or in addition to topical antibiotics when MRSA-biofilm wound infection is suspected.

Indexed as

Methicillin-Resistant Staphylococcus aureusSkin Diseases, InfectiousSoft Tissue InjuriesWound InfectionAnimalsAnti-Bacterial AgentsBiofilmsGentian VioletIodidesMiceStaphylococcus aureusAnti-Bacterial AgentsGentian VioletIodidesLugol's solutionbiofilmgentian violetLugol's solutionMRSAStaphylococcus aureus

Identifiers

PMID35633295
PMCPMC9797939
OpenAlexW4281634233

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.