ArticleJournal of magnetic resonance imaging : JMRI2023
Global Aortic Pulse Wave Velocity is Unchanged in Bicuspid Aortopathy With Normal Valve Function but Elevated in Patients With Aortic Valve Stenosis: Insights From a 4D Flow MRI Study of 597 Subjects.
Article in Journal of magnetic resonance imaging : JMRI, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed, 11 citations in OpenAlex.
- Backward Aortic Flow Is Associated with Impaired Left Ventricular Mechanics in Young Adults with Bicuspid Aortic Valve: A Prospective Cardiovascular Magnetic Resonance Study.Journal of clinical medicine · 2026Article
- 4D Flow MRI derived aortic pulse wave velocity and wall shear stress in Covid-19.Clinical imaging · 2025Article
- A Fully Automated Analysis Pipeline for 4D Flow MRI in the Aorta.Bioengineering (Basel, Switzerland) · 2025Article
- Robustness of 4D flow MRI derived aortic wall shear stress and pulse wave velocity across different protocols in healthy controls and in patients with bicuspid aortic valve.The international journal of cardiovascular imaging · 2025Article
- Novel Techniques in Imaging Congenital Heart Disease: JACC Scientific Statement.Journal of the American College of Cardiology · 2024Review
- Feasibility of Wave Intensity Analysis from 4D Cardiovascular Magnetic Resonance Imaging Data.Bioengineering (Basel, Switzerland) · 2023Article
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Authors and funding
11 authors at 3 institutions in 3 countries.
Funding
Abstract
backgroundAortopathy is common with bicuspid aortic valve (BAV), and underlying intrinsic tissue abnormalities are believed causative. Valve-mediated hemodynamics are altered in BAV and may contribute to aortopathy and its progression. The contribution of intrinsic tissue defects versus altered hemodynamics to aortopathy progression is not known. PURPOSE: To investigate relative contributions of tissue-innate versus hemodynamics in progression of BAV aortopathy. STUDY TYPE: Retrospective. SUBJECTS: Four hundred seventy-three patients with aortic dilatation (diameter ≥40 mm; comprised of 281 BAV with varied AS severity, 192 tricuspid aortic valve [TAV] without AS) and 124 healthy controls. Subjects were 19-91 years (141/24% female). FIELD STRENGTH/SEQUENCE: 1.5T, 3T; time-resolved gradient-echo 3D phase-contrast (4D flow) MRI. ASSESSMENT: A surrogate measure for global aortic wall stiffness, pulse wave velocity (PWV), was quantified from MRI by standardized, automated technique based on through-plane flow cross-correlation maximization. Comparisons were made between BAV patients with aortic dilatation and varying aortic valve stenosis (AS) severity and healthy subjects and aortopathy patients with normal TAV. STATISTICAL TESTS: Multivariable regression, analysis of covariance (ANCOVA), Tukey's, student's (t), Mann-Whitney (U) tests, were used with significance levels P < 0.05 or P < 0.01 for post-hoc Bonferroni-corrected t/U tests. Bland-Altman and ICC calculations were performed.
resultsMultivariable regression showed age with the most significant association for increased PWV in all groups (increase 0.073-0.156 m/sec/year, R DATA
conclusionNo significant PWV differences were observed between BAV patients with normal valve function and control groups. However, AS severity and age in BAV patients were directly associated with PWV increases. EVIDENCE LEVEL: 3 TECHNICAL EFFICACY: Stage 3.
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