ArticleHuman brain mapping2022
In vivo structural connectome of arousal and motor brainstem nuclei by 7 Tesla and 3 Tesla MRI.
Article in Human brain mapping, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Orofacial Central Pattern Generators: Neuroanatomical and Clinical Insights into Sensory, Motor, Emotional Integration.Experimental neurobiology · 2026Review
- Structure-function coupling in the human brainstem.bioRxiv : the preprint server for biology · 2026Article
- MRI methods for the study of central nervous system involvement in autonomic function.Frontiers in network physiology · 2026Review
- MRI-derived atrophy in multiple system atrophy aligns with mitochondrial and glial gene expression patterns.NPJ Parkinson's disease · 2025Article
- Transcranial Direct Current Stimulation in Older Adolescent with Chronic Mild Traumatic Brain Injury: A Case Study of Clinical and Functional Connectivity.Research square · 2025Article
- Structural connectome construction using constrained spherical deconvolution in multi-shell diffusion-weighted magnetic resonance imaging.Nature protocols · 2025Review
- A sensation driven functional MRI study on brain activation during bladder filling in healthy participants.Scientific reports · 2025Article
- Terra Incognita - Contributions of the Olivo-Cerebellar System to Autism Spectrum Disorder.Cerebellum (London, England) · 2025Review
- Selective Effects of Substantia Nigra and Locus Coeruleus Degeneration on Cognition in Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2025Article
- Automated parcellation and atlasing of the human subcortex with ultra-high resolution quantitative MRI.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Integrating brainstem and cortical functional architectures.Nature neuroscience · 2024Article
- Integrating brainstem and cortical functional architectures.Research square · 2023Article
- Integrating brainstem and cortical functional architectures.bioRxiv : the preprint server for biology · 2023Article
- Direct localization and delineation of human pedunculopontine nucleus based on a self-supervised magnetic resonance image super-resolution method.Human brain mapping · 2023Article
- In vivo structural connectome of arousal and motor brainstem nuclei by 7 Tesla and 3 Tesla MRI.Human brain mapping · 2022Article
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Authors and funding
4 authors.
Funding
Abstract
Brainstem nuclei are key participants in the generation and maintenance of arousal, which is a basic function that modulates wakefulness/sleep, autonomic responses, affect, attention, and consciousness. Their mechanism is based on diffuse pathways ascending from the brainstem to the thalamus, hypothalamus, basal forebrain and cortex. Several arousal brainstem nuclei also participate in motor functions that allow humans to respond and interact with the surrounding through a multipathway motor network. Yet, little is known about the structural connectivity of arousal and motor brainstem nuclei in living humans. This is due to the lack of appropriate tools able to accurately visualize brainstem nuclei in conventional imaging. Using a recently developed in vivo probabilistic brainstem nuclei atlas and 7 Tesla diffusion-weighted images (DWI), we built the structural connectome of 18 arousal and motor brainstem nuclei in living humans (n = 19). Furthermore, to investigate the translatability of our findings to standard clinical MRI, we acquired 3 Tesla DWI on the same subjects, and measured the association of the connectome across scanners. For both arousal and motor circuits, our results showed high connectivity within brainstem nuclei, and with expected subcortical and cortical structures based on animal studies. The association between 3 Tesla and 7 Tesla connectivity values was good, especially within the brainstem. The resulting structural connectome might be used as a baseline to better understand arousal and motor functions in health and disease in humans.
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