Evidence map›Paper›PMID 35633200›Full record

SynthesisBirth defects research2022

Analysis of early neonatal case fatality rate among newborns with congenital hydrocephalus, a 2000-2014 multi-country registry-based study.

Juan Antonio Gili, Jorge Santiago López-Camelo, Wendy N Nembhard, Marian Bakker, Hermien E K de Walle, Erin B Stallings, Vijaya Kancherla, ECEMC Peripheral Group, Paolo Contiero, Saeed Dastgiri and 20 more

Open access · bronzeAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Birth defects research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Prevalence of Congenital Anomalies in Iran.Archives of Iranian medicine · 2024
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

30 authors at 20 institutions in 18 countries.

Juan Antonio GiliECLAMC, Centro de Educación Médica e Investigaciones Clínicas (CEMIC-CONICET), Buenos Aires, Argentina.ORCID 0000-0001-7924-0776
Jorge Santiago López-CameloECLAMC, Centro de Educación Médica e Investigaciones Clínicas (CEMIC-CONICET), Buenos Aires, Argentina.
Wendy N NembhardDepartment of Epidemiology, Arkansas Center for Birth Defects Research and Prevention and Arkansas Reproductive Health Monitoring System, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.ORCID 0000-0002-8318-4049
Marian BakkerDepartment of Genetics, University of Groningen, University Medical Center Groningen, EUROCAT Northern Netherlands, Groningen, The Netherlands.
Hermien E K de WalleDepartment of Genetics, University of Groningen, University Medical Center Groningen, EUROCAT Northern Netherlands, Groningen, The Netherlands.
Erin B StallingsMetro Atlanta Congenital Defects Program (MACDP), Division of Birth Defects and Infant Disorders, National Center on Birth Defects and Developmental Disabilities, CDC, Atlanta, Georgia, USA.ORCID 0000-0002-0461-1410
Vijaya KancherlaDepartment of Epidemiology, Emory University Rollins School of Public Health, Atlanta, Georgia, USA.ORCID 0000-0002-2803-8030
ECEMC Peripheral GroupAs listed in http://www.fundacion1000.es/Estructura-del-ECEMC for year 2021, Spain.
Paolo ContieroLombardy Congenital Anomalies Registry, Cancer Registry Unit, Fondazione IRCCS, Istituto Nazionale Tumori, Milan, Italy.
Saeed DastgiriHealth Services Management Research Centre, Tabriz University of Medical Sciences, Tabriz, Iran.
Marcia L FeldkampDivision of Medical Genetics, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, Utah, USA.ORCID 0000-0001-9171-7848
Amy NanceUtah Birth Defect Network, Bureau of Children with Special Health Care Needs, Division of Family Health and Preparedness, Utah Department of Health, Salt Lake City, Utah, USA.ORCID 0000-0002-4326-890X
Miriam GattMalta Congenital Anomalies Registry, Directorate for Health Information and Research, Tal-Pietà, Malta.
Laura MartínezGenetics Department, Hospital Universitario Dr. José E. González, Universidad Autonóma de Nuevo León, San Nicolás de los Garza, Mexico.
María Aurora CanessaRegional Register Congenital Malformation Maule Health Service (RRMC-SSM), Maule, Chile.
Boris GroismanNational Network of Congenital Anomalies of Argentina (RENAC), National Center of Medical Genetics, National Administration of Laboratories and Health Institutes (ANLIS), National Ministry of Health and Social Development, Buenos Aires, Argentina.ORCID 0000-0001-6263-2562
Paula Hurtado-VillaDepartment of Basic Sciences of Health, School of Health, Pontificia Universidad Javeriana, Cali, Colombia.ORCID 0000-0003-3822-7780
Karin KällénNational Board of Health and Welfare, Stockholm, Sweden.
Danielle LandauDepartment of Neonatology, Soroka Medical Center, Beer-Sheva, Israel.
Nathalie LelongUniversité de Paris, CRESS Obstetrical, Perinatal and Pediatric Epidemiology Research Team (EPOPé), INSERM, INRA, Paris, France.
Margery MorganCARIS, The Congenital Anomaly Register for Wales, Singleton Hospital, Swansea, Wales, UK.
Jazmín Arteaga-VázquezDepartment of Genetics, RYVEMCE, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, México City, Mexico.
Anna PieriniInstitute of Clinical Physiology, National Research Council and Fondazione Toscana Gabriele Monasterio, Tuscany Registry of Congenital Defects, Pisa, Italy.
Anke RissmannMedical Faculty, Malformation Monitoring Centre Saxony-Anhalt, Otto-von-Guericke University, Magdeburg, Germany.ORCID 0000-0002-9437-2790
Antonin SipekDepartment of Medical Genetics, Thomayer University Hospital, Prague, Czech Republic.
Elena SzabovaSlovak Teratologic Information Centre (FPH), Slovak Medical University, Bratislava, Slovak Republic.
Wladimir WerteleckiOmni-Net for Children International Charitable Fund, Rivne, Ukraine.ORCID 0000-0001-5864-5985
Ignacio ZaranteHuman Genetics Institute, Pontificia Universidad Javeriana, Bogotá, Colombia.ORCID 0000-0002-0729-6866
Mark A CanfieldBirth Defects Epidemiology and Surveillance Branch, Texas Department of State Health Services, Austin, Texas, USA.
Pierpaolo MastroiacovoInternational Center on Birth Defects, International Clearinghouse for Birth Defects Surveillance and Research, Rome, Italy.
Consejo Nacional de Investigaciones Científicas y Técnicas · ARInserm · FRNational Board of Health and Welfare · SENational Center on Birth Defects and Developmental Disabilities · USPontificia Universidad Javeriana · COSlovak Medical University · SKTabriz University of Medical Sciences · IRTexas Department of State Health Services · USUniversidad Autónoma de Nuevo León · MXUniversity Medical Center Groningen · NLAdministración Nacional de Laboratorios e Institutos de Salud · AREmory University · USFondazione Toscana Gabriele Monasterio · ITFundación para el Desarrollo de la Ecología · BOInstituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán · MXSingleton Hospital · GBThomayer University Hospital · CZUniversity of Arkansas for Medical Sciences · USUniversity of Utah · USUtah Department of Health · US

Funding

Intramural CDC HHS CC999999
6 · The paper itself

Abstract

backgroundCongenital hydrocephalus (CH) comprises a heterogeneous group of birth anomalies with a wide-ranging prevalence across geographic regions and registry type. The aim of the present study was to analyze the early neonatal case fatality rate (CFR) and total birth prevalence of newborns diagnosed with CH.

methodsData were provided by 25 registries from four continents participating in the International Clearinghouse for Birth Defects Surveillance and Research (ICBDSR) on births ascertained between 2000 and 2014. Two CH rates were calculated using a Poisson distribution: early neonatal CFR (death within 7 days) per 100 liveborn CH cases (CFR) and total birth prevalence rate (BPR) per 10,000 births (including live births and stillbirths) (BPR). Heterogeneity between registries was calculated using a meta-analysis approach with random effects. Temporal trends in CFR and BPR within registries were evaluated through Poisson regression modeling.

resultsA total of 13,112 CH cases among 19,293,280 total births were analyzed. The early neonatal CFR was 5.9 per 100 liveborn cases, 95% confidence interval (CI): 5.4-6.8. The CFR among syndromic cases was 2.7 times (95% CI: 2.2-3.3) higher than among non-syndromic cases (10.4% [95% CI: 9.3-11.7] and 4.4% [95% CI: 3.7-5.2], respectively). The total BPR was 6.8 per 10,000 births (95% CI: 6.7-6.9). Stratified by elective termination of pregnancy for fetal anomalies (ETOPFA), region and system, higher CFR were observed alongside higher BPR rates. The early neonatal CFR and total BPR did not show temporal variation, with the exception of a CFR decrease in one registry.

conclusionsFindings of early neonatal CFR and total BPR were highly heterogeneous among registries participating in ICBDSR. Most registries with higher CFR also had higher BPR. Differences were attributable to type of registry (hospital-based vs. population-based), ETOPFA (allowed yes or no) and geographical regions. These findings contribute to the understanding of regional differences of CH occurrence and early neonatal deaths.

Indexed as

HydrocephalusStillbirthFemaleHumansInfant, NewbornLive BirthPregnancyPrevalenceRegistriesbirth defectscase fatality ratecongenital hydrocephalusearly neonatal deathsETOPFApopulation surveillanceprevalencetrends

Identifiers

PMID35633200
PMCPMC9288486
OpenAlexW4281694135

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.