ArticleThe journal of vascular access2024
The SIP protocol update: Eight strategies, incorporating Rapid Peripheral Vein Assessment (RaPeVA), to minimize complications associated with peripherally inserted central catheter insertion.
Article in The journal of vascular access, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07519304 (Effectiveness of a Needle-free Connector With Anti-reflux Technology in Reducing Complications From Long Peripheral Venous Catheters in Hospitalised Adult Patients), which is not on this map. Cited by 36 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effectiveness of a Needle-free Connector With Anti-reflux Technology in Reducing Complications From Long Peripheral Venous Catheters in Hospitalised Adult Patients: Randomised Clinical Trial
Who cites it
36 citing papers in PubMed, 3 syntheses or guidelines pooled it, 138 citations in OpenAlex.
- [Clinical practice guideline for point-of-care ultrasound-guided peripherally inserted central catheter placement in neonates (2026)].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2026Guideline
- Complications of tunneled and non-tunneled peripherally inserted central catheter placement in chemotherapy-treated cancer patients: a meta-analysis.Frontiers in surgery · 2024Pooled it
- Prevention of complications related to peripherally inserted central catheter insertion techniques in newborns: systematic review and network meta-analysis.Revista latino-americana de enfermagem · 2024Pooled it
- Clinical benefit of adding cyanoacrylate glue during PICC line insertion compared to standard procedure in outpatient cancer patients: Results from the randomized prospective trial PICCandGLUE.The journal of vascular access · 2026Trial
- Exit site management: neonatal european vascular access team - ESPR recommendation 7.Pediatric research · 2026Article
- Peripherally inserted central catheters versus central venous catheters in critically ill patients under standardized insertion protocols: a propensity score-matched cohort study.BMC anesthesiology · 2026Article
- Risk Factors for Catheter-Related Thrombosis.Journal of clinical medicine · 2026Article
- Design and Protocol of a Randomised Controlled Trial Evaluating Virtual Reality to Improve Patient Experience During PICC and PICC-PORT Placement in Oncology Patients.Nursing reports (Pavia, Italy) · 2026Article
- A GAVeCeLT bundle for chest-port insertion: The SIC-Port protocol.The journal of vascular access · 2026Article
- Current status of and factors influencing difficult catheter advancement in neonatal PICC insertion: a prospective multicenter observational study.European journal of pediatrics · 2026Observational
- Article
- A Novel Modified Ultrasound-Guided Venipuncture Technique for Non-Tunneled PICC Insertion in a Non-Operating Room Anesthesia (NORA) Setting: A Technical Report with Real-World Experience.Journal of clinical medicine · 2026Article
- Vascular access in the newborn: a position paper of Neonatal European Vascular Access Teams (NEVAT).European journal of pediatrics · 2026Review
- Ultrasound-Guided, Guidewire-Assisted Long Peripheral Catheter in the Great Saphenous Vein for Bilateral Upper Limb Fracture Surgery: A Case Report.Case reports in anesthesiology · 2026Article
- Comparison of two blunt dissection sheath insertion techniques in peripherally inserted central catheter placement: a randomized non-inferiority trial.Frontiers in medicine · 2026Article
- Risk factors associated with mortality in patients with catheter-related and catheter-associated bloodstream infections: a retrospective observational study focused on CVADs and midlines.Antimicrobial resistance and infection control · 2025Observational
- Insertion-related complications after central venous catheterization in onco-hematologic children: A prospective clinical study.European journal of pediatrics · 2025Article
- Effectiveness of Vascular Catheter Removal Versus Retention in Non-ICU Patients with CRBSI or CABSI in Retrospective, Single-Center Study.Microorganisms · 2025Article
- Appropriate tourniquet pressure for peripherally inserted central catheter placement in the upper arm.Journal of anesthesia · 2025Article
- Prevention of Peripherally Inserted Central Catheter (PICC)-Associated Vein Thrombosis in Cancer: A Narrative Review.Biomedicines · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Insertion of Peripherally Inserted Central Catheters (PICCs) is potentially associated with the risk of immediate/early adverse events, some of them minimal (repeated punctures) and some relevant (accidental arterial puncture or nerve-related injury). Several strategies adopted during the insertion process may minimize the risk of such events, including late complication risks such as infection, venous thrombosis, or catheter dislodgment and/or malposition. This paper describes an update version of the SIP protocol (Safe Insertion of PICCs), an insertion bundle which includes eight effective strategies that aims to minimize immediate, early, or late insertion-associated complications. These strategies include: preprocedural ultrasound assessment utilizing the RaPeVA (Rapid Peripheral Venous Assessment) protocol; appropriate skin antiseptic technique; choice of appropriate vein, adoption of the Zone Insertion Method™; clear identification of the median nerve and brachial artery; ultrasound-guided puncture; ultrasound-guided tip navigation; intra-procedural assessment of tip location; correct securement of the catheter, and appropriate protection of the exit site. This updated version of the SIP protocol includes several novelties based on the most recent evidence-based scientific literature on PICC insertion, such as the clinical relevance of the tunneling technique, the use of ultrasound for intra-procedural tip navigation and tip location, and the new technologies for the protection of the exit site (cyanoacrylate glue) and for the securement of the catheter (subcutaneous anchorage).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.