ArticleJournal of veterinary internal medicine2022
Environmental risk factors for the development of oral squamous cell carcinoma in cats.
Article in Journal of veterinary internal medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 25 citations in OpenAlex.
- Association Between Urinary Cotinine and Whole-Slide Digital Cytomorphometric Alterations in the Oral Mucosa of Tobacco Smoke-Exposed Cats.Veterinary sciences · 2026Article
- A Retrospective Study on the Histological and Clinical Features of 92 Feline Oral Neoplasms in Thailand.Animals : an open access journal from MDPI · 2026Article
- Mapping Feline Oncology in Portugal: A National Characterization.Animals : an open access journal from MDPI · 2026Article
- Secondhand smoke and e-cigarette aerosol exposure in dogs and cats: A scoping review with implications for smoking cessation among pet owners.Tobacco prevention & cessation · 2026Review
- High expression of prostaglandin EP4 receptor mRNA in feline head and neck squamous cell carcinoma.Canadian journal of veterinary research = Revue canadienne de recherche veterinaire · 2025Article
- Oral squamous cell carcinoma: Insights into cellular heterogeneity, drug resistance, and evolutionary trajectories.Cell biology and toxicology · 2025Review
- Treatment of feline oral squamous cell carcinoma with accelerated radiation and carboplatin with and without follow-up toceranib phosphate.Journal of feline medicine and surgery · 2025Article
- Comparative analysis of IscM and IscQu in feline oral squamous cell carcinoma treatment: cytotoxic and apoptotic insights.Frontiers in veterinary science · 2025Article
- Feline oral squamous cell carcinoma: recent advances and future perspectives.Frontiers in veterinary science · 2025Review
- Gingival squamous cell carcinoma in 2 lions under managed care.Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc · 2024Article
- Case report: Allogeneic feline umbilical cord-derived mesenchymal stem cell transplantation for feline oral squamous cell carcinoma.Frontiers in veterinary science · 2024Article
- Effect of ethanol extract fromOpen veterinary journal · 2023Article
- Feline Oral Squamous Cell Carcinoma: A Critical Review of Etiologic Factors.Veterinary sciences · 2022Review
- Environmental risk factors for the development of oral squamous cell carcinoma in cats.Journal of veterinary internal medicine · 2022Article
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundRisk factors for oral squamous cell carcinoma (OSCC) in cats are derived from a single study dated almost 20 years ago. The relationship between inflammation of oral tissues and OSCC is still unclear.
objectivesTo investigate previously proposed and novel potential risk factors for OSCC development, including oral inflammatory diseases. ANIMALS: Hundred cats with OSCC, 70 cats with chronic gingivostomatitis (CGS), 63 cats with periodontal disease (PD), and 500 controls.
methodsProspective, observational case-control study. Cats with OSCC were compared with an age-matched control sample of client-owned cats and cats with CGS or PD. Owners of cats completed an anonymous questionnaire including demographic, environmental and lifestyle information.
resultsOn multivariable logistic regression, covariates significantly associated with an increased risk of OSCC were rural environment (OR: 1.77; 95% CI: 1.03-3.04; P = .04), outdoor access (OR: 1.68; 95% CI: 1.07-2.63; P = .02), environmental tobacco smoke (OR: 1.77; 95% CI: 1.05-3; P = .03), and petfood containing chemical additives (OR: 1.98; 95% CI: 1.04-3.76; P = .04). Risk factors shared with CGS and PD were outdoor access and petfood containing chemical additives, respectively. A history of oral inflammation was reported in 35% of cats with OSCC but did not emerge as a risk factor. CONCLUSIONS AND CLINICAL IMPORTANCE: The study proposes novel potential risk factors for OSCC in cats. Although a history of inflammatory oral disease was not significantly more frequent compared with random age-matched controls, OSCC shared several risk factors with CGS and PD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.