ArticleAlcoholism, clinical and experimental research2022
The development, but not expression, of alcohol front-loading in C57BL/6J mice maintained on LabDiet 5001 is abolished by maintenance on Teklad 2920x rodent diet.
Article in Alcoholism, clinical and experimental research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Adolescent Alcohol and Stress Exposure Rewires Key Cortical Neurocircuitry.Frontiers in neuroscience · 2022Pooled it
- Comparative analysis of test tube and volumetric drinking monitor methods in voluntary ethanol consumption in female mice for prenatal alcohol exposure.Toxicology reports · 2026Article
- Gonadal Sex and Sex-Chromosome Complement Interact to Affect Ethanol Consumption in Adolescent Four Core Genotypes Mice.Brain sciences · 2026Article
- Alcohol consumption in P301S mice accelerates gait impairments, modifies aggregation of pathological tau and alters microglia within the hippocampus.Alcohol, clinical & experimental research · 2025Article
- Impact of plastic sipper devices on alcohol self-administration in rodents: Limitations for long-term access paradigms.Alcohol (Fayetteville, N.Y.) · 2025Article
- Maternal alcohol drinking patterns predict offspring neurobehavioral outcomes.Neuropharmacology · 2024Article
- Sex differences in neural networks recruited by frontloaded binge alcohol drinking.Addiction biology · 2024Article
- Engagement for alcohol escalates in the 5-choice serial reaction time task after intermittent access.Alcohol (Fayetteville, N.Y.) · 2024Article
- Standard rodent diets differentially impact alcohol consumption and preference and gut microbiome diversity.bioRxiv : the preprint server for biology · 2024Article
- Non-consummatory behavior signals predict aversion-resistant alcohol drinking in head-fixed mice.Neuropharmacology · 2024Article
- Standard rodent diets differentially impact alcohol consumption, preference, and gut microbiome diversity.Frontiers in neuroscience · 2024Article
- Long-term effects of low prenatal alcohol exposure on GABAergic interneurons of the murine posterior parietal cortex.Alcohol, clinical & experimental research · 2023Article
- Non-Consummatory Behavior Signals Predict Aversion-Resistant Alcohol Drinking in Head-Fixed Mice.bioRxiv : the preprint server for biology · 2023Article
- Impact of two different rodent diets on maternal ethanol consumption, serum ethanol concentration and pregnancy outcome measures.Alcohol (Fayetteville, N.Y.) · 2023Article
- Agmatine reduces alcohol drinking and produces antinociceptive effects in rodent models of alcohol use disorder.Alcohol (Fayetteville, N.Y.) · 2023Article
- Microbial glutamate metabolism predicts intravenous cocaine self-administration in diversity outbred mice.Neuropharmacology · 2023Article
- Adaptation of the 5-choice serial reaction time task to measure engagement and motivation for alcohol in mice.Frontiers in behavioral neuroscience · 2022Article
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3 authors at 1 institution in 1 country.
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Abstract
backgroundExcessive alcohol (ethanol) consumption, such as binge drinking, is extremely commonplace and represents a major health concern. Through modeling excessive drinking in rodents, we are beginning to uncover the neurobiological and neurobehavioral causes and consequences of this pattern of ethanol intake. One important factor for modeling binge drinking in mice is that they reliably drink to blood ethanol concentrations (BECs) of 80 mg/dl or higher. Drinking-in-the-dark (DID) is a commonly used mouse model of binge drinking, and we have shown that this method reliably results in robust ethanol front-loading and binge-level BECs in C57BL/6J (B6) mice and other ethanol-preferring mouse strains/lines. However, establishing the DID model in a new vivarium space forced us to consider the use of rodent diet formulations that we had not previously used.
methodsThe current set of experiments were designed to investigate the role of two standard rodent diet formulations on binge drinking and the development of ethanol front-loading using DID.
resultsWe found that BECs in animals maintained on LabDiet 5001 (LD01) were double those found in mice maintained on Teklad 2920x (TL20). Interestingly, this effect was paralleled by differences in the degree of front-loading, such that LD01-fed mice consumed approximately twice as much ethanol in the first 15 min of the 2-h DID sessions as the TL20-fed mice. Surprisingly, however, mice that developed front-loading during maintenance on the LD01 diet continued to display front-loading behavior after being switched to the TL20 diet.
conclusionsThese data emphasize the importance of choosing and reporting diet formulations when conducting voluntary drinking studies and support the need for further investigation into the mechanisms behind diet-induced differences in binge drinking, particularly front-loading.
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