Evidence map›Paper›PMID 35632784›Full record

ArticleViruses2022

Clearance of Persistent SARS-CoV-2 RNA Detection in a NFκB-Deficient Patient in Association with the Ingestion of Human Breast Milk: A Case Report.

Janine S Sabino, Mariene R Amorim, William M de Souza, Lia F Marega, Luciana S Mofatto, Daniel A Toledo-Teixeira, Julia Forato, Rodrigo G Stabeli, Maria Laura Costa, Fernando R Spilki and 10 more

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Viruses, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
  3. Selective IgA Deficiency May Be an Underrecognized Risk Factor for Severe COVID-19.The journal of allergy and clinical immunology. In practice · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 5 institutions in 3 countries.

Janine S SabinoLaboratory of Pediatric Immunology, Center for Investigation in Pediatrics, Faculty of Medical Sciences, University of Campinas, Campinas 13083-887, Brazil.ORCID 0000-0001-6502-1206
Mariene R AmorimLaboratory of Emerging Viruses, Department of Genetics, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas 13083-862, Brazil.ORCID 0000-0002-8516-0155
William M de SouzaWorld Reference Center for Emerging Viruses, Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA.
Lia F MaregaLaboratory of Pediatric Immunology, Center for Investigation in Pediatrics, Faculty of Medical Sciences, University of Campinas, Campinas 13083-887, Brazil.
Luciana S MofattoLaboratory of Emerging Viruses, Department of Genetics, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas 13083-862, Brazil.
Daniel A Toledo-TeixeiraLaboratory of Emerging Viruses, Department of Genetics, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas 13083-862, Brazil.ORCID 0000-0002-4055-058X
Julia ForatoLaboratory of Emerging Viruses, Department of Genetics, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas 13083-862, Brazil.
Rodrigo G StabeliOswaldo Cruz Foundation (Fiocruz-SP), Ribeirão Preto 14049-900, Brazil.ORCID 0000-0002-0476-920X
Maria Laura CostaDepartment of Obstetrics and Gynecology, Faculty of Medical Sciences, University of Campinas, Campinas 13083-887, Brazil.
Fernando R SpilkiOne Health Laboratory, Feevale University, Novo Hamburgo 93510-235, Brazil.ORCID 0000-0001-5804-7045
Ester C SabinoTropical Medicine Institute, Medical School, University of São Paulo, São Paulo 5403-907, Brazil.
Nuno R FariaDepartment of Infectious and Parasitic Disease, Medical School, University of São Paulo, São Paulo 05403-000, Brazil.
Bruno D BenitesHematology and Transfusion Medicine Center, University of Campinas, Campinas 13083-878, Brazil.ORCID 0000-0003-3985-5690
Marcelo Addas-CarvalhoHematology and Transfusion Medicine Center, University of Campinas, Campinas 13083-878, Brazil.ORCID 0000-0003-0178-6191
Raquel S B StucchiDivision of Infectious Diseases, University of Campinas, Campinas 13083-887, Brazil.
Dewton M VasconcelosLaboratory of Investigation in Dermatology and Immunodeficiencies, Department of Dermatology, Medical School, University of São Paulo, São Paulo 05403-000, Brazil.
Scott C WeaverWorld Reference Center for Emerging Viruses, Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA.ORCID 0000-0001-8016-8556
Fabiana GranjaLaboratory of Emerging Viruses, Department of Genetics, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas 13083-862, Brazil.ORCID 0000-0003-3602-8550
José Luiz Proenca-ModenaLaboratory of Emerging Viruses, Department of Genetics, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas 13083-862, Brazil.ORCID 0000-0002-4996-3153
Maria Marluce Dos S VilelaLaboratory of Pediatric Immunology, Center for Investigation in Pediatrics, Faculty of Medical Sciences, University of Campinas, Campinas 13083-887, Brazil.
Universidade Estadual de Campinas (UNICAMP) · BRUniversidade de São Paulo · BRThe University of Texas Medical Branch at Galveston · USFundação Oswaldo Cruz · BRUniversidade Feevale · BR

Funding

World Reference Center for Emerging Viruses and Arboviruses (WRCEVA)R24AI120942 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI WEAVER, SCOTT C · 2016 to 2024
$8.5M
Medical Research Council MR/R015600/1Medical Research Council MR/S0195/1Medical Research Council MR/S019510/1NIAID NIH HHS R24 AI120942
6 · The paper itself

Abstract

Currently, there are no evidence-based treatment options for long COVID-19, and it is known that SARS-CoV-2 can persist in part of the infected patients, especially those with immunosuppression. Since there is a robust secretion of SARS-CoV-2-specific highly-neutralizing IgA antibodies in breast milk, and because this immunoglobulin plays an essential role against respiratory virus infection in mucosa cells, being, in addition, more potent in neutralizing SARS-CoV-2 than IgG, here we report the clinical course of an NFκB-deficient patient chronically infected with the SARS-CoV-2 Gamma variant, who, after a non-full effective treatment with plasma infusion, received breast milk from a vaccinated mother by oral route as treatment for COVID-19. After such treatment, the symptoms improved, and the patient was systematically tested negative for SARS-CoV-2. Thus, we hypothesize that IgA and IgG secreted antibodies present in breast milk could be useful to treat persistent SARS-CoV-2 infection in immunodeficient patients.

Indexed as

COVID-19SARS-CoV-2Antibodies, ViralEatingFemaleHumansImmunoglobulin AImmunoglobulin GMilk, HumanNF-kappa BPost-Acute COVID-19 SyndromeRNA, ViralAntibodies, ViralImmunoglobulin AImmunoglobulin GNF-kappa BRNA, Viralbreast milkIgAimmunosuppressionNFκB-deficiencypersistent SARS-CoV-2 infection

Identifiers

PMID35632784
PMCPMC9143223
OpenAlexW4280524564

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.