Evidence map›Paper›PMID 35632778›Full record

ReviewViruses2022

SARS-CoV-2 Infection and Possible Neonatal Neurological Outcomes: A Literature Review.

Flávia Maciel de Moraes, Julia Werneck Paulino Soares de Souza, Letícia Pires Alves, Milena Ferreira Ribeiro de Siqueira, Ana Paula Aguiar Dos Santos, Mariana Monteiro de Carvalho Berardo, Marcelo Gomes Granja, Hugo Caire de Castro-Faria-Neto

Open access · goldAbstract readReview
In one paragraph

Review in Viruses, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

Flávia Maciel de MoraesPrograma de Pós-Graduação em Biologia Molecular e Celular, Universidade Federal do Estado do Rio de Janeiro-UNIRIO, Rua Frei Caneca, 94-Centro, Rio de Janeiro 20211-010, Brazil.
Julia Werneck Paulino Soares de SouzaInstituto de Educação Médica-IDOMED, Escola de Medicina, Universidade Estácio de Sá, Avenida Presidente Vargas, 1121-Centro, Rio de Janeiro 20071-004, Brazil.ORCID 0000-0003-0186-353X
Letícia Pires AlvesPrograma de Pós-Graduação em Biologia Molecular e Celular, Universidade Federal do Estado do Rio de Janeiro-UNIRIO, Rua Frei Caneca, 94-Centro, Rio de Janeiro 20211-010, Brazil.
Milena Ferreira Ribeiro de SiqueiraFaculdade de Biomedicina, Instituto Biomédico, Universidade Federal Fluminense, Rua Ernani Melo, 101-São Domingos, Niterói 24210-130, Brazil.
Ana Paula Aguiar Dos SantosEscola de Medicina, Fundação Técnico-Educacional Souza Marques, Avenida Ernani Cardoso, 335-Cascadura, Rio de Janeiro 20020-080, Brazil.
Mariana Monteiro de Carvalho BerardoInstituto de Educação Médica-IDOMED, Escola de Medicina, Universidade Estácio de Sá, Avenida Presidente Vargas, 1121-Centro, Rio de Janeiro 20071-004, Brazil.
Marcelo Gomes GranjaLaboratório de Imunofarmacologia, Fundação Oswaldo Cruz-Fiocruz, Avenida Brasil, 4365-Manguinhos, Rio de Janeiro 21045-900, Brazil.
Hugo Caire de Castro-Faria-NetoLaboratório de Imunofarmacologia, Fundação Oswaldo Cruz-Fiocruz, Avenida Brasil, 4365-Manguinhos, Rio de Janeiro 21045-900, Brazil.
Estácio (Brazil) · BRFundação Oswaldo Cruz · BRUniversidade Federal do Estado do Rio de Janeiro · BRFundação Técnico Educacional Souza Marques · BRUniversidade Federal Fluminense · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The virus responsible for COVID-19 is designated "severe acute respiratory syndrome coronavirus 2" (SARS-CoV-2), a highly transmissible and pathogenic coronavirus. Although people of all ages are susceptible to SARS-CoV-2 infection, clinical manifestations may vary with age. The response of neonates to SARS-CoV-2 infection or exposure differs from that of children and adults. Encephalitis due to viral infections in the central nervous system (CNS) and childhood multisystem inflammatory syndrome (MIS-C) are some of the possible neonatal consequences of SARS-CoV-2 infection. This review aims to verify possible neonatal neurological outcomes after SARS-CoV-2 infection. Overall, the cellular and molecular basis of the neurological sequelae of SARS-CoV-2 in neonates remains unclear, and attempts to elucidate the pathophysiology of COVID-19 involve a comparison with the mechanism of other viral diseases. There are a considerable number of case reports in the literature exploring neurological outcomes in the neonatal period. In this review, we present possible effects of SARS-CoV-2 in neonates, emphasizing the importance of monitoring this group. The mechanisms of SARS-CoV-2 entry into the CNS have not yet been fully elucidated, and the potential severity of SARS-CoV-2 infection in neonates, as well as the possible short- and long-term neurological sequelae, remain unclear.

Indexed as

COVID-19ChildHumansInfant, NewbornSARS-CoV-2Systemic Inflammatory Response Syndromebrainneonatal infectionsneurological outcomesSARS-CoV-2

Identifiers

PMID35632778
PMCPMC9143946
OpenAlexW4280620548

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.