Evidence map›Paper›PMID 35632755›Full record

ArticleViruses2022

Exposure Route Influences Disease Severity in the COVID-19 Cynomolgus Macaque Model.

Sandra L Bixler, Christopher P Stefan, Alexandra N Jay, Franco D Rossi, Keersten M Ricks, Charles J Shoemaker, Alicia M Moreau, Xiankun Zeng, Jay W Hooper, David N Dyer and 20 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Viruses, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

30 authors.

Sandra L BixlerVirology Division, United States Army Medical Research Institute of Infectious Diseases (USAMRIID), Fort Detrick, Frederick, MD 21702, USA.ORCID 0000-0002-1960-1311
Christopher P StefanDiagnostic Systems Division, USAMRIID, Fort Detrick, Frederick, MD 21702, USA.ORCID 0000-0003-4891-447X
Alexandra N JayVeterinary Medicine Division, USAMRIID, Fort Detrick, Frederick, MD 21702, USA.ORCID 0000-0002-5246-6940
Franco D RossiVeterinary Medicine Division, USAMRIID, Fort Detrick, Frederick, MD 21702, USA.
Keersten M RicksDiagnostic Systems Division, USAMRIID, Fort Detrick, Frederick, MD 21702, USA.
Charles J ShoemakerDiagnostic Systems Division, USAMRIID, Fort Detrick, Frederick, MD 21702, USA.
Alicia M MoreauPathology Division, USAMRIID, Fort Detrick, Frederick, MD 21702, USA.
Xiankun ZengPathology Division, USAMRIID, Fort Detrick, Frederick, MD 21702, USA.
Jay W HooperVirology Division, United States Army Medical Research Institute of Infectious Diseases (USAMRIID), Fort Detrick, Frederick, MD 21702, USA.
David N DyerVeterinary Medicine Division, USAMRIID, Fort Detrick, Frederick, MD 21702, USA.
Ondraya M FrickVeterinary Medicine Division, USAMRIID, Fort Detrick, Frederick, MD 21702, USA.
Jeffrey W KoehlerDiagnostic Systems Division, USAMRIID, Fort Detrick, Frederick, MD 21702, USA.
Brian J KearneyCore Laboratory Services, USAMRIID, Fort Detrick, Frederick, MD 21702, USA.
Nina DiPintoPathology Division, USAMRIID, Fort Detrick, Frederick, MD 21702, USA.
Jun LiuPathology Division, USAMRIID, Fort Detrick, Frederick, MD 21702, USA.
Samantha D TostensonCore Laboratory Services, USAMRIID, Fort Detrick, Frederick, MD 21702, USA.ORCID 0000-0002-6234-4891
Tamara L ClementsDiagnostic Systems Division, USAMRIID, Fort Detrick, Frederick, MD 21702, USA.
Jeffrey M SmithVirology Division, United States Army Medical Research Institute of Infectious Diseases (USAMRIID), Fort Detrick, Frederick, MD 21702, USA.
Joshua A JohnsonCore Laboratory Services, USAMRIID, Fort Detrick, Frederick, MD 21702, USA.ORCID 0000-0002-6285-6571
Kerry L BerrierVeterinary Medicine Division, USAMRIID, Fort Detrick, Frederick, MD 21702, USA.
Heather L EshamVeterinary Medicine Division, USAMRIID, Fort Detrick, Frederick, MD 21702, USA.
Korey L DelpDiagnostic Systems Division, USAMRIID, Fort Detrick, Frederick, MD 21702, USA.
Susan R CoyneDiagnostic Systems Division, USAMRIID, Fort Detrick, Frederick, MD 21702, USA.
Holly A BloomfieldCore Laboratory Services, USAMRIID, Fort Detrick, Frederick, MD 21702, USA.
Paul A KuehnertDiagnostic Systems Division, USAMRIID, Fort Detrick, Frederick, MD 21702, USA.
Kristen AkersCore Laboratory Services, USAMRIID, Fort Detrick, Frederick, MD 21702, USA.
Kathleen M GibsonCore Laboratory Services, USAMRIID, Fort Detrick, Frederick, MD 21702, USA.
Timothy D MinogueDiagnostic Systems Division, USAMRIID, Fort Detrick, Frederick, MD 21702, USA.
Aysegul NalcaCore Support Directorate, USAMRIID, Fort Detrick, Frederick, MD 21702, USA.ORCID 0000-0001-8581-7535
Margaret L M PittOffice of the Science Advisor, USAMRIID, Fort Detrick, Frederick, MD 21702, USA.ORCID 0000-0003-0080-3260

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The emergence of SARS-CoV-2 and the subsequent pandemic has highlighted the need for animal models that faithfully replicate the salient features of COVID-19 disease in humans. These models are necessary for the rapid selection, testing, and evaluation of potential medical countermeasures. Here, we performed a direct comparison of two distinct routes of SARS-CoV-2 exposure-combined intratracheal/intranasal and small particle aerosol-in two nonhuman primate species, rhesus and cynomolgus macaques. While all four experimental groups displayed very few outward clinical signs, evidence of mild to moderate respiratory disease was present on radiographs and at necropsy. Cynomolgus macaques exposed via the aerosol route also developed the most consistent fever responses and had the most severe respiratory disease and pathology. This study demonstrates that while all four models produced suitable representations of mild COVID-like illness, aerosol exposure of cynomolgus macaques to SARS-CoV-2 produced the most severe disease, which may provide additional clinical endpoints for evaluating therapeutics and vaccines.

Indexed as

COVID-19AerosolsAnimalsDisease Models, AnimalMacaca fascicularisSARS-CoV-2Severity of Illness IndexAerosolsaerosolanimal modelsCOVIDnonhuman primatepathologySARS-CoV-2

Identifiers

PMID35632755
PMCPMC9145782

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.