Evidence map›Paper›PMID 35632572›Full record

ReviewVaccines2022

Harnessing the Immune System with Cancer Vaccines: From Prevention to Therapeutics.

Ilene Le, Subramanian Dhandayuthapani, Jessica Chacon, Anna M Eiring, Shrikanth S Gadad

Open access · goldAbstract readReview
In one paragraph

Review in Vaccines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
  2. Article
  3. Natural carrier systems in cancer vaccines and immunotherapy.Human vaccines & immunotherapeutics · 2025
    Review
  4. Biodistribution studies ofApplied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine · 2025
    Article
  5. Review
  6. Review
  7. Article
  8. Review
  9. Review
  10. Review
  11. Development of ELISA Assay for Antibody Detection in Cancer Vaccine Research.Methods in molecular biology (Clifton, N.J.) · 2025
    Article
  12. Review
  13. Review
  14. Therapeutic Vaccines for Follicular Lymphoma: A Systematic Review.Pharmaceuticals (Basel, Switzerland) · 2024
    Review
  15. Review
  16. Review
  17. Review
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Ilene LePaul L. Foster School of Medicine, Texas Tech University Health Sciences Center El Paso, El Paso, TX 79905, USA.
Subramanian DhandayuthapaniPaul L. Foster School of Medicine, Texas Tech University Health Sciences Center El Paso, El Paso, TX 79905, USA.
Jessica ChaconPaul L. Foster School of Medicine, Texas Tech University Health Sciences Center El Paso, El Paso, TX 79905, USA.
Anna M EiringPaul L. Foster School of Medicine, Texas Tech University Health Sciences Center El Paso, El Paso, TX 79905, USA.ORCID 0000-0001-6533-9150
Shrikanth S GadadPaul L. Foster School of Medicine, Texas Tech University Health Sciences Center El Paso, El Paso, TX 79905, USA.ORCID 0000-0003-0030-5472
Texas Tech University · US

Funding

A Novel Hyper-Immunogenic Low Virulent BCG vaccine against TuberculosisR01AI175837 · NIAID · UNIVERSITY OF TEXAS RIO GRANDE VALLEY · PI SUBRAMANIAN DHANDAYUTHAPANI · 2023 to 2026
$2.0M
G0S2 in Chronic Myeloid Leukemia Disease Progression and Imatinib ResistanceK22CA216008 · NCI · TEXAS TECH UNIVERSITY HEALTH SCIS CENTER · PI EIRING, ANNA MARIE · 2018 to 2021
$704k
A novel quadruple knockout MTb vaccine against tuberculosis (Supplement Resubmission)R15AI156647 · NIAID · TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER AT EL PASO · PI DHANDAYUTHAPANI, SUBRAMANIAN · 2021 to 2023
$626k
NCI NIH HHS K22 CA216008NIAID NIH HHS R01 AI175837NIAID NIH HHS R15 AI156647
6 · The paper itself

Abstract

Prophylactic vaccination against infectious diseases is one of the most successful public health measures of our lifetime. More recently, therapeutic vaccination against established diseases such as cancer has proven to be more challenging. In the host, cancer cells evade immunologic regulation by multiple means, including altering the antigens expressed on their cell surface or recruiting inflammatory cells that repress immune surveillance. Nevertheless, recent clinical data suggest that two classes of antigens show efficacy for the development of anticancer vaccines: tumor-associated antigens and neoantigens. In addition, many different vaccines derived from antigens based on cellular, peptide/protein, and genomic components are in development to establish their efficacy in cancer therapy. Some vaccines have shown promising results, which may lead to favorable outcomes when combined with standard therapeutic approaches. This review provides an overview of the innate and adaptive immune systems, their interactions with cancer cells, and the development of various different vaccines for use in anticancer therapeutics.

Indexed as

antigenscancercancer vaccinesimmunotherapy

Identifiers

PMID35632572
PMCPMC9146235
OpenAlexW4281254544

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.