Evidence map›Paper›PMID 35632505›Full record

ArticleVaccines2022

COVID-19 Vaccines Confer Protection in Hospitalized Pregnant and Postpartum Women with Severe COVID-19: A Retrospective Cohort Study.

Cristiane de Freitas Paganoti, Rafaela Alkmin da Costa, Aris T Papageorghiou, Fabrício da Silva Costa, Silvana Maria Quintana, Luciana Graziela de Godoi, Nátaly Adriana Jiménez Monroy, Agatha Sacramento Rodrigues, Rossana Pulcineli Vieira Francisco

Open access · goldAbstract read
In one paragraph

Article in Vaccines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
7.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.

  1. Pooled it
  2. Gamma SARS-CoV-2 variant of concern infection repercussions on pregnancy outcomes: A translational cohort study.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 3 countries.

Cristiane de Freitas PaganotiDivisão de Clinica Obstetrica, Hospital das Clinicas HCFMUSP, Faculdade de Medicina da Universidade de São Paulo, 255 Dr Eneas Carvalho de Aguiar Avenue, 10th floor, São Paulo 05403-000, Brazil.
Rafaela Alkmin da CostaDivisão de Clinica Obstetrica, Hospital das Clinicas HCFMUSP, Faculdade de Medicina da Universidade de São Paulo, 255 Dr Eneas Carvalho de Aguiar Avenue, 10th floor, São Paulo 05403-000, Brazil.ORCID 0000-0001-8828-6725
Aris T PapageorghiouNuffield Department of Women's and Reproductive Health, University of Oxford, Women's Centre, John Radcliffe Hospital, Headington, Oxford OX3 9DU, UK.
Fabrício da Silva CostaMaternal Fetal Medicine Unit, Gold Coast University Hospital, School of Medicine, Griffith University, Gold Coast 4222, Australia.ORCID 0000-0002-0765-7780
Silvana Maria QuintanaGynecology and Obstetric Department, Ribeirão Preto Medical School, University of São Paulo, 3900 Bandeirantes Avenue, Ribeirão Preto, São Paulo 14049-900, Brazil.
Luciana Graziela de GodoiDepartamento de Estatística, Universidade Federal do Espírito Santo, 514 Fernando Ferrari Avenue, Goiabeira, Vitória 29075-910, Brazil.
Nátaly Adriana Jiménez MonroyDepartamento de Estatística, Universidade Federal do Espírito Santo, 514 Fernando Ferrari Avenue, Goiabeira, Vitória 29075-910, Brazil.
Agatha Sacramento RodriguesDepartamento de Estatística, Universidade Federal do Espírito Santo, 514 Fernando Ferrari Avenue, Goiabeira, Vitória 29075-910, Brazil.
Rossana Pulcineli Vieira FranciscoDisciplina de Obstetrícia, Departamento de Obstetrícia e Ginecologia, Hospital das Clinicas HCFMUSP, Faculdade de Medicina da Universidade de São Paulo, São Paulo 05508-070, Brazil.ORCID 0000-0002-9981-8069
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo · BRUniversidade Federal do Espírito Santo · BRGriffith University · AUJohn Radcliffe Hospital · GBUniversidade de São Paulo · BR

Funding

Bill & Melinda Gates Foundation 027961Fundação de Amparo à Pesquisa do Espírito Santo 007/2021Gates Foundation INV-027961National Council for Scientific and Technological Development 445881/2020-8
6 · The paper itself

Abstract

The coronavirus disease 2019 (COVID-19) pandemic has had deleterious effects among the obstetric population. Pregnant and postpartum women constitute a high-risk group for severe COVID-19. Vaccination reduces the risk of infection, but it is not known whether women who become infected despite vaccination have a milder course of disease than those who had not been vaccinated. This retrospective cohort study evaluated whether vaccination reduces the severity of COVID-19 infection, as measured by severe maternal morbidity and mortality among hospitalized pregnant and postpartum individuals. A total of 2284 pregnant and postpartum women hospitalized with severe COVID-19 were included. Those who did and who did not receive COVID-19 vaccination were compared. The rates of intensive care unit admission, intubation, and mortality were significantly lower among subjects in the vaccinated group (p < 0.001, p < 0.001 and p < 0.001, respectively). The numbers of patients who needed to be vaccinated to avoid one case of intensive care unit admission, intubation, or death due to COVID-19 were 7, 7, and 9, respectively. The COVID-19 vaccine offers protective effects against intensive care unit admission, intubation, and death in hospitalized pregnant and postpartum women with severe SARS-CoV-2-induced SARS.

Indexed as

COVID-19 vaccinesintensive care unitintubationmaternal mortalitypregnancysevere acute respiratory syndrome

Identifiers

PMID35632505
PMCPMC9146232
OpenAlexW4280501890

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.