Evidence map›Paper›PMID 35632473›Full record

ArticleVaccines2022

A SARS-CoV-2 Spike Ferritin Nanoparticle Vaccine Is Protective and Promotes a Strong Immunological Response in the Cynomolgus Macaque Coronavirus Disease 2019 (COVID-19) Model.

Sara C Johnston, Keersten M Ricks, Ines Lakhal-Naouar, Alexandra Jay, Caroline Subra, Jo Lynne Raymond, Hannah A D King, Franco Rossi, Tamara L Clements, David Fetterer and 34 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Vaccines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.8field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
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  10. Review
  11. Review
  12. A novel view of ferritin in cancer.Biochimica et biophysica acta. Reviews on cancer · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

44 authors at 3 institutions in 1 country.

Sara C JohnstonVirology Division, United States Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA.
Keersten M RicksDiagnostic Systems Division, United States Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA.
Ines Lakhal-NaouarHenry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.
Alexandra JayVeterinary Medicine Division, United States Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA.ORCID 0000-0002-5246-6940
Caroline SubraHenry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.ORCID 0000-0001-5272-0972
Jo Lynne RaymondPathology Division, United States Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA.
Hannah A D KingHenry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.
Franco RossiVeterinary Medicine Division, United States Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA.
Tamara L ClementsDiagnostic Systems Division, United States Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA.
David FettererVeterinary Medicine Division, United States Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA.
Samantha TostensonCore Laboratory Services Division, United States Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA.ORCID 0000-0002-6234-4891
Camila Macedo CincottaHenry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.
Holly R HackHenry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.
Caitlin KuklisViral Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.ORCID 0000-0002-9974-6640
Sandrine SomanViral Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
Jocelyn KingViral Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
Kristina K PeachmanDiagnostics and Countermeasures Branch, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.ORCID 0000-0001-8568-1439
Dohoon KimHenry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.
Wei-Hung ChenHenry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.
Rajeshwer S SankhalaHenry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.
Elizabeth J MartinezHenry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.ORCID 0000-0002-7755-7056
Agnes HajduczkiHenry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.
William C ChangHenry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.ORCID 0000-0003-4967-6426
Misook ChoeHenry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.
Paul V ThomasHenry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.
Caroline E PetersonHenry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.ORCID 0000-0002-6087-7301
Alexander AndersonHenry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.ORCID 0000-0002-0000-7734
Isabella SwaffordHenry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.
Jeffrey R CurrierViral Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
Dominic Paquin-ProulxHenry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.ORCID 0000-0003-1407-3414
Linda L JagodzinskiDiagnostics and Countermeasures Branch, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
Gary R MatyasU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.ORCID 0000-0002-2074-2373
Mangala RaoU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
Gregory D GromowskiViral Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
Sheila A PeelDiagnostics and Countermeasures Branch, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
Lauren WhiteVeterinary Medicine Division, United States Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA.
Jeffrey M SmithVirology Division, United States Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA.
Jay W HooperVirology Division, United States Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA.
Nelson L MichaelCenter for Infectious Diseases Research, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.ORCID 0000-0001-5882-5548
Kayvon ModjarradEmerging Infectious Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
M Gordon JoyceHenry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.
Aysegul NalcaCore Support Directorate, United States Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA.ORCID 0000-0001-8581-7535
Diane L BoltonHenry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.
Margaret L M PittOffice of the Science Advisor, United States Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA.ORCID 0000-0003-0080-3260
Henry M. Jackson Foundation · USUnited States Army Medical Research Institute of Infectious Diseases · USWalter Reed Army Institute of Research · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The COVID-19 pandemic has had a staggering impact on social, economic, and public health systems worldwide. Vaccine development and mobilization against SARS-CoV-2 (the etiologic agent of COVID-19) has been rapid. However, novel strategies are still necessary to slow the pandemic, and this includes new approaches to vaccine development and/or delivery that will improve vaccination compliance and demonstrate efficacy against emerging variants. Here, we report on the immunogenicity and efficacy of a SARS-CoV-2 vaccine comprising stabilized, pre-fusion spike protein trimers displayed on a ferritin nanoparticle (SpFN) adjuvanted with either conventional aluminum hydroxide or the Army Liposomal Formulation QS-21 (ALFQ) in a cynomolgus macaque COVID-19 model. Vaccination resulted in robust cell-mediated and humoral responses and a significant reduction in lung lesions following SARS-CoV-2 infection. The strength of the immune response suggests that dose sparing through reduced or single dosing in primates may be possible with this vaccine. Overall, the data support further evaluation of SpFN as a SARS-CoV-2 protein-based vaccine candidate with attention to fractional dosing and schedule optimization.

Indexed as

aluminum hydroxideArmy Liposomal Formulation QS-21COVID-19ferritin nanoparticleprimateSARS-CoV-2SpFNvaccine

Identifiers

PMID35632473
PMCPMC9145473
OpenAlexW4225378644

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.