Active Aberration Correction with Adaptive Coefficient SPGD Algorithm for Laser Scanning Confocal Microscope.

Kunhua Zhou, Zhizheng Wu, Tianyu Zhang, Feng Li, Azhar Iqbal, Suresh Sivanandam

Abstract read

In one paragraph

Article in Sensors (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Kunhua ZhouDepartment of Precision Mechanical Engineering, Shanghai University, Shanghai 200444, China.

Zhizheng WuDepartment of Precision Mechanical Engineering, Shanghai University, Shanghai 200444, China.

Tianyu ZhangDepartment of Precision Mechanical Engineering, Shanghai University, Shanghai 200444, China.

Feng LiSchool of Optical-Electrical and Computer Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China.

Azhar IqbalDunlap Institute for Astronomy and Astrophysics, University of Toronto, Toronto, ON M5S 3H4, Canada.

Suresh SivanandamDunlap Institute for Astronomy and Astrophysics, University of Toronto, Toronto, ON M5S 3H4, Canada.

Funding

National Natural Science Foundation of China 52075315, 51675321

6 · The paper itself

Abstract

A laser scanning confocal microscope (LSCM) is an effective scientific instrument for studying sub-micron structures, and it has been widely used in the field of biological detection. However, the illumination depth of LSCMs is limited due to the optical aberrations introduced by living biological tissue, which acts as an optical medium with a non-uniform refractive index, resulting in a significant dispersion of the focus of LSCM illumination light and, hence, a loss in the resolution of the image. In this study, to minimize the effect of optical aberrations, an image-based adaptive optics technology using an optimized stochastic parallel gradient descent (SPGD) algorithm with an adaptive coefficient is applied to the optical path of an LSCM system. The effectiveness of the proposed aberration correction approach is experimentally evaluated in the LSCM system. The results illustrate that the proposed adaptive optics system with an adaptive coefficient SPGD algorithm can effectively reduce the interference caused by aberrations during depth imaging.

Indexed as

AlgorithmsOptics and PhotonicsLasersMicroscopy, Confocalaberrationsadaptive opticsdepth imaginglaser scanning confocal microscopeSPGD

Identifiers

PMID35632164

DOI10.3390/s22103755

PMCPMC9147356

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.