Evidence map›Paper›PMID 35631901›Full record

ArticlePolymers2022

Synthesis of Coumarin Derivatives: A New Class of Coumarin-Based G Protein-Coupled Receptor Activators and Inhibitors.

Zhe Fu, Linjie Zhang, Sijin Hang, Shiyi Wang, Na Li, Xiaojing Sun, Zian Wang, Ruilong Sheng, Fang Wang, Wenhui Wu and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Polymers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Zhe FuCollege of Food Science and Technology, Shanghai Ocean University, Shanghai 201306, China.
Linjie ZhangCollege of Food Science and Technology, Shanghai Ocean University, Shanghai 201306, China.
Sijin HangCollege of Food Science and Technology, Shanghai Ocean University, Shanghai 201306, China.
Shiyi WangAIEN Institute, Shanghai Ocean University, Shanghai 201306, China.
Na LiCollege of Food Science and Technology, Shanghai Ocean University, Shanghai 201306, China.
Xiaojing SunCollege of Food Science and Technology, Shanghai Ocean University, Shanghai 201306, China.
Zian WangCollege of Food Science and Technology, Shanghai Ocean University, Shanghai 201306, China.
Ruilong ShengCQM-Centro de Química da Madeira, Campus da Penteada, Universidade da Madeira, 9000-390 Funchal, Portugal.ORCID 0000-0002-3303-3832
Fang WangSchool Basic Medicine, Shanghai University of Medicine and Health Science, Shanghai 201318, China.
Wenhui WuCollege of Food Science and Technology, Shanghai Ocean University, Shanghai 201306, China.ORCID 0000-0002-1710-8582
Ruihua GuoCollege of Food Science and Technology, Shanghai Ocean University, Shanghai 201306, China.ORCID 0000-0001-8414-886X
Shanghai Ocean University · CNCenter for High Pressure Science & Technology Advanced Research · CNShanghai University of Medicine and Health Sciences · CNUniversidade da Madeira · PT

Funding

ARDITI-Agência Regional para o Desenvolvimento da Investigação Tecnologia e Inovação through the project M1420-01-0145-FEDER-000005-CQM+(Madeira 14-20 Program)and ARDITI-CQM-2017- ISG-003FCT-Fundação para a Ciência e a Tecnologia UIDB/00674/2020 and 2021.00453.CEECINDNational Natural Science Foundation of China No. 81502955the Doctoral Scientific Research Foundation of Shanghai Ocean University No. A2030214300077the Young Teachers Training Program of Shanghai No. A12056160002
6 · The paper itself

Abstract

To expand the range of daphnetin-based inhibitors/activators used for targeting G protein-coupled receptors (GPCRs) in disease treatment, twenty-five coumarin derivatives 1-25, including 7,8-dihydroxycoumarin and 7-hydroxycoumarin derivatives with various substitution patterns/groups at C3-/4- positions, were synthesized via mild Pechmann condensation and hydroxyl modification. The structures were characterized by

Indexed as

coumarinG protein-coupled receptorsstructure–activity relationshipssynthesis

Identifiers

PMID35631901
PMCPMC9147790
OpenAlexW4280599508

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.