ArticlePlants (Basel, Switzerland)2022
A Genome-Wide Association Study Identifying Single-Nucleotide Polymorphisms for Iron and Zinc Biofortification in a Worldwide Barley Collection.
Article in Plants (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 21 citations in OpenAlex.
- Introgression of barley chromosome arms 4H and 6H into wheat via Robertsonian translocations: GBS-assisted structural analysis and impact on grain nutrient composition.Plant molecular biology · 2026Article
- Quality Parameters of Wort Produced with Lentil Malt with the Use of Some Enzymatic Preparations.Foods (Basel, Switzerland) · 2025Article
- Article
- Genome-wide association study and expression of candidate genes for Fe and Zn concentration in sorghum grains.Scientific reports · 2024Article
- Genomic loci associated with grain protein and mineral nutrients concentrations inFrontiers in plant science · 2024Article
- Plant Iron Research in African Countries: Current "Hot Spots", Approaches, and Potentialities.Plants (Basel, Switzerland) · 2023Review
- Deciphering the genetic diversity and population structure of wild barley germplasm against corn leaf aphid, Rhopalosiphum maidis (Fitch).Scientific reports · 2023Article
- Mapping QTL for Mineral Accumulation and Shoot Dry Biomass in Barley under Different Levels of Zinc Supply.International journal of molecular sciences · 2023Article
- Modelling climate variabilities and global rice production: A panel regression and time series analysis.Heliyon · 2023Article
- Biofortification to avoid malnutrition in humans in a changing climate: Enhancing micronutrient bioavailability in seed, tuber, and storage roots.Frontiers in plant science · 2023Review
- Genetic diversity and population structure analyses in barley (Frontiers in plant science · 2023Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Micronutrient deficiency affects half of the world’s population, mostly in developing countries. Severe health issues such as anemia and inadequate growth in children below five years of age and pregnant women have been linked to mineral deficiencies (mostly zinc and iron). Improving the mineral content in staple crops, also known as mineral biofortification, remains the best approach to address mineral malnutrition. Barley is a staple crop in some parts of the world and is a healthy choice since it contains β-glucan, a high dietary protein. Barley mineral biofortification, especially with zinc and iron, can be beneficial since barley easily adapts to marginalized areas and requires less input than other frequently consumed cereals. In this study, we analyzed zinc and iron content in 496 barley samples. The samples were genotyped with an Illumina 50 K SNP chip. Genome-wide association studies (GWAS) identified 62 SNPs and 68 SNPs (p < 0.001) associated with iron and zinc content in grains, respectively. After a Bonferroni correction (p < 0.005), there were 12 SNPs (single-nucleotide polymorphism) associated with Zn and 6 for iron. SNP annotations revealed proteins involved in membrane transport, Zn and Fe binding, linked to nutrient remobilization in grains. These results can be used to develop biofortified barley via marker-assisted selection (MAS), which could alleviate mineral malnutrition.
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Registered trials
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