Evidence map›Paper›PMID 35631719›Full record

ArticlePlants (Basel, Switzerland)2022

In Vitro Anti-Proliferative, and Kinase Inhibitory Activity of Phenanthroindolizidine Alkaloids Isolated from

Ehab M Mostafa, Hamdoon A Mohammed, Arafa Musa, Mohamed A Abdelgawad, Mohammad M Al-Sanea, Suliman A Almahmoud, Mohammed M Ghoneim, Hesham A M Gomaa, Fatema El-Zahraa S Abdel Rahman, Khaled Shalaby and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Plants (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Stevia Leaf Extract Fermented with Plant-DerivedInternational journal of molecular sciences · 2025
    Article
  2. Article
  3. Review
  4. Phenanthroindolizidine Alkaloids Isolated fromInternational journal of molecular sciences · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Ehab M MostafaDepartment of Pharmacognosy, College of Pharmacy, Jouf University, Sakaka 72341, Saudi Arabia.ORCID 0000-0001-8841-9786
Hamdoon A MohammedDepartment of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, Qassim University, Buraydah 51452, Saudi Arabia.ORCID 0000-0003-2896-6790
Arafa MusaDepartment of Pharmacognosy, College of Pharmacy, Jouf University, Sakaka 72341, Saudi Arabia.ORCID 0000-0003-0979-556X
Mohamed A AbdelgawadDepartment of Pharmaceutical Chemistry, College of Pharmacy, Jouf University, Sakaka 72341, Saudi Arabia.ORCID 0000-0001-9035-5638
Mohammad M Al-SaneaDepartment of Pharmaceutical Chemistry, College of Pharmacy, Jouf University, Sakaka 72341, Saudi Arabia.ORCID 0000-0002-9820-4022
Suliman A AlmahmoudDepartment of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, Qassim University, Buraydah 51452, Saudi Arabia.
Mohammed M GhoneimDepartment of Pharmacognosy and Medicinal Plants, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo 11884, Egypt.ORCID 0000-0002-9179-4373
Hesham A M GomaaDepartment of Pharmacology, College of Pharmacy, Jouf University, Sakaka 72341, Saudi Arabia.ORCID 0000-0001-7510-8428
Fatema El-Zahraa S Abdel RahmanDepartment of Basic Sciences, Faculty of Oral and Dental Medicine, Nahda University, Beni-Suef 62511, Egypt.
Khaled ShalabyDepartment of Pharmaceutics, College of Pharmacy, Jouf University, Sakaka 72341, Saudi Arabia.
Samy SelimDepartment of Clinical Laboratory Sciences, College of Applied Medical Sciences, Jouf University, Sakaka 72388, Saudi Arabia.ORCID 0000-0003-4025-8586
Riaz A KhanDepartment of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, Qassim University, Buraydah 51452, Saudi Arabia.ORCID 0000-0003-0185-0149
Jouf University · SAQassim University · SAAl-Azhar University · EGNahda University · EG

Funding

Deanship of Scientific Research at Jouf University DSR-2021-01-0102
6 · The paper itself

Abstract

The phenanthroindolizidine alkaloid (-)-tylophorine has been reported for its significant anticancer activity working through different biomechanistic pathways. The current study aimed to evaluate the anticancer activity of phenanthroindolizidine alkaloids isolated from

Indexed as

alkaloidsanticancer activityanti-proliferativekinase inhibitionphenanthroindolizidineQSPRquantitative structure properties relationshipreceptor dockingTylophora indicatylophorines

Identifiers

PMID35631719
PMCPMC9144581
OpenAlexW4280552792

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.