Evidence map›Paper›PMID 35631669›Full record

ArticlePharmaceutics2022

Targeting Peptide, Fluorescent Reagent Modified Magnetic Liposomes Coated with Rapamycin Target Early Atherosclerotic Plaque and Therapy.

Chen Huang, Wentao Huang, Lifen Zhang, Chunyu Zhang, Chengqian Zhou, Wei Wei, Yongsheng Li, Quan Zhou, Wenli Chen, Yukuan Tang

Open access · goldAbstract read
In one paragraph

Article in Pharmaceutics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 27 citations in OpenAlex.

  1. Review
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  11. How Advanced Is Nanomedicine for Atherosclerosis?International journal of nanomedicine · 2025
    Review
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  17. Article
  18. Advances in Atherosclerosis Theranostics Harnessing Iron Oxide-Based Nanoparticles.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Chen HuangDepartment of Minimally Invasive Interventional Radiology, Guangzhou Panyu Central Hospital, Guangzhou 511400, China.
Wentao HuangMOE Key Laboratory of Laser Life Science & Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou 510631, China.ORCID 0000-0002-2257-4502
Lifen ZhangMOE Key Laboratory of Laser Life Science & Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou 510631, China.
Chunyu ZhangMOE Key Laboratory of Laser Life Science & Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou 510631, China.
Chengqian ZhouNeuroscience Laboratory, Hugo Moser Research Institute at Kennedy Krieger, Baltimore, MD 21205, USA.
Wei WeiInstitution of Guang Dong Cord Blood Bank, Guangzhou 510700, China.
Yongsheng LiInstitution of Guang Dong Cord Blood Bank, Guangzhou 510700, China.
Quan ZhouDepartment of Radiology, The Third Affiliated Hospital of Southern Medical University, Guangzhou 510630, China.
Wenli ChenMOE Key Laboratory of Laser Life Science & Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou 510631, China.ORCID 0000-0002-4768-3844
Yukuan TangDepartment of Minimally Invasive Interventional Radiology, Guangzhou Panyu Central Hospital, Guangzhou 511400, China.
South China Normal University · CNGuangzhou Blood Center · CNPanyu District Central Hospital · CNKennedy Krieger Institute · USThird Affiliated Hospital of Southern Medical University · CN

Funding

Guangdong Medical Science and Technology Research Foundation B2021376Guangzhou Science and Technology Planning Project 202103000002National Natural Science Foundation of China 81471659Panyu Major Science and Technology Planning Project 2020-Z04-002the Science and Technology Project of Guangzhou 201805010002
6 · The paper itself

Abstract

Atherosclerosis is the leading cause of global morbidity and mortality. Its therapy requires research in several areas, such as diagnosis of early arteriosclerosis, improvement of the pharmacokinetics and bioavailability of rapamycin as its therapeutic agents. Here, we used the targeting peptide VHPKQHR (VHP) (or fluorescent reagent) to modify the phospholipid molecules to target vascular cell adhesion molecule-1 (VCAM-1) and loaded ultrasmall paramagnetic iron oxide (USPIO/Fe

Indexed as

bimodal imagingearly atherosclerosisMRIrapamycinRap/Fe3O4@VHP-LipoVCAM-1

Identifiers

PMID35631669
PMCPMC9146689
OpenAlexW4280613426

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.