Evidence map›Paper›PMID 35631617›Full record

ArticlePharmaceutics2022

Formulation and Evaluation of SNEDDS Loaded with Original Lipophenol for the Oral Route to Prevent Dry AMD and Stragardt's Disease.

Maxime Vincent, Laurianne Simon, Philippe Brabet, Philippe Legrand, Christophe Dorandeu, Josephine Lai Kee Him, Thierry Durand, Céline Crauste, Sylvie Begu

Open access · goldAbstract read
In one paragraph

Article in Pharmaceutics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.4field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Maxime VincentICGM, Univ Montpellier, CNRS, ENSCM, 34000 Montpellier, France.
Laurianne SimonICGM, Univ Montpellier, CNRS, ENSCM, 34000 Montpellier, France.ORCID 0000-0002-8515-947X
Philippe BrabetInstitut des Neurosciences de Montpellier, INSERM U1051, 34000 Montpellier, France.ORCID 0000-0003-2739-1622
Philippe LegrandICGM, Univ Montpellier, CNRS, ENSCM, 34000 Montpellier, France.
Christophe DorandeuICGM, Univ Montpellier, CNRS, ENSCM, 34000 Montpellier, France.
Josephine Lai Kee HimCentre de Biochimie Structurale, CNRS UMR 5048, INSERM U1054, 34000 Montpellier, France.ORCID 0000-0001-6303-1224
Thierry DurandIBMM, Univ Montpellier, CNRS, ENSCM, 34000 Montpellier, France.
Céline CrausteIBMM, Univ Montpellier, CNRS, ENSCM, 34000 Montpellier, France.ORCID 0000-0002-5714-8749
Sylvie BeguICGM, Univ Montpellier, CNRS, ENSCM, 34000 Montpellier, France.
École Nationale Supérieure de Chimie de Montpellier · FRCentre National de la Recherche Scientifique · FRInserm · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dry age-related macular degeneration (Dry AMD) and Stargardt's disease (STGD1) are common eye diseases, characterized by oxidative and carbonyl stress (COS)-inducing photoreceptor degeneration and vision loss. Previous studies have demonstrated the protective effect of photoreceptors after the intravenous administration of a new lipophenol drug, phloroglucinol-isopropyl-DHA (IP-DHA). In this study, we developed an oral formulation of IP-DHA (BCS Class IV) relying on a self-nanoemulsifying drug delivery system (SNEDDS). SNEDDS, composed of Phosal

Indexed as

antioxidantdry age-related macular degeneration (AMD)lipophenoloral deliveryself-nanoemulsifying drug delivery system (SNEDDS)Stargardt’s disease (STGD1)

Identifiers

PMID35631617
PMCPMC9147958
OpenAlexW4280607012

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.