Evidence map›Paper›PMID 35631599›Full record

ArticlePharmaceutics2022

Intranasal Immunization with Zika Virus Envelope Domain III-Flagellin Fusion Protein Elicits Systemic and Mucosal Immune Responses and Protection against Subcutaneous and Intravaginal Virus Challenges.

Chi-Hsun Chen, Chung-Chu Chen, Wei-Bo Wang, Vania Lionel, Chia-Chyi Liu, Li-Min Huang, Suh-Chin Wu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceutics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
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  8. Naïve CD4International journal of molecular sciences · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Chi-Hsun ChenInstitute of Biotechnology, National Tsing Hua University, Hsinchu 30013, Taiwan.
Chung-Chu ChenDepartment of Internal Medicine, MacKay Memorial Hospital, Hsinchu 30071, Taiwan.ORCID 0000-0003-4415-7811
Wei-Bo WangInstitute of Biotechnology, National Tsing Hua University, Hsinchu 30013, Taiwan.
Vania LionelInstitute of Biotechnology, National Tsing Hua University, Hsinchu 30013, Taiwan.
Chia-Chyi LiuNational Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Zhunan 35053, Taiwan.
Li-Min HuangDepartment of Pediatrics, National Taiwan University Hospital, Taipei 10041, Taiwan.ORCID 0000-0002-9291-260X
Suh-Chin WuInstitute of Biotechnology, National Tsing Hua University, Hsinchu 30013, Taiwan.
National Tsing Hua University · TWMinghsin University of Science and Technology · TWNational Health Research Institutes · TWNational Taiwan University Hospital · TW

Funding

Ministry of Science and Technology MOST110-2327-B-007-004, MOST109-2313-B-007-001-MY2
6 · The paper itself

Abstract

Zika virus (ZIKV) infections in humans are mainly transmitted by the mosquito vectors, but human-to-human sexual transmission is also another important route. Developing a ZIKV mucosal vaccine that can elicit both systemic and mucosal immune responses is of particular interest. In this study, we constructed a recombinant ZIKV envelope DIII (ZDIII) protein genetically fused with

Indexed as

domain IIIintranasal immunizationmucosal vaccineZika virus

Identifiers

PMID35631599
PMCPMC9144594
OpenAlexW4229372385

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.