Evidence map›Paper›PMID 35631503›Full record

ReviewPharmaceutics2022

Nanotheranostics for Image-Guided Cancer Treatment.

Isabel S Dennahy, Zheng Han, William M MacCuaig, Hunter M Chalfant, Anna Condacse, Jordan M Hagood, Juan C Claros-Sorto, Wajeeha Razaq, Jennifer Holter-Chakrabarty, Ronald Squires and 3 more

Open access · goldAbstract readReview
In one paragraph

Review in Pharmaceutics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 45 citations in OpenAlex.

  1. Article
  2. Dendrimers-based Hydrogels and Nanogels for Drug Delivery.Current pharmaceutical biotechnology · 2026
    Review
  3. A multifunctional FeFrontiers in bioengineering and biotechnology · 2026
    Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Review
  9. Review
  10. Precision Oncology: Advances in Drug Delivery and Imaging.Recent advances in drug delivery and formulation · 2025
    Review
  11. Review
  12. Review
  13. Review
  14. Review
  15. Review
  16. Recent nanotheranostic approaches in cancer research.Clinical and experimental medicine · 2024
    Review
  17. Biomedical Approach of Nanotechnology and Biological Risks: A Mini-Review.International journal of molecular sciences · 2023
    Review
  18. Article
  19. Review
  20. Functionalization of and through Melanin: Strategies and Bio-Applications.International journal of molecular sciences · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Isabel S DennahyDepartment of Surgery, University of Oklahoma Health Science Center, Oklahoma City, OK 73104, USA.ORCID 0000-0002-4778-8910
Zheng HanDepartment of Surgery, University of Oklahoma Health Science Center, Oklahoma City, OK 73104, USA.
William M MacCuaigDepartment of Bioengineering, University of Oklahoma, Norman, OK 73019, USA.
Hunter M ChalfantDepartment of Surgery, University of Oklahoma Health Science Center, Oklahoma City, OK 73104, USA.
Anna CondacseDepartment of Surgery, University of Oklahoma Health Science Center, Oklahoma City, OK 73104, USA.ORCID 0000-0001-5689-8567
Jordan M HagoodDepartment of Surgery, University of Oklahoma Health Science Center, Oklahoma City, OK 73104, USA.
Juan C Claros-SortoDepartment of Surgery, University of Oklahoma Health Science Center, Oklahoma City, OK 73104, USA.
Wajeeha RazaqDepartment of Internal Medicine, University of Oklahoma Health Science Center, Oklahoma City, OK 73104, USA.
Jennifer Holter-ChakrabartyDepartment of Internal Medicine, University of Oklahoma Health Science Center, Oklahoma City, OK 73104, USA.
Ronald SquiresDepartment of Surgery, University of Oklahoma Health Science Center, Oklahoma City, OK 73104, USA.
Barish H EdilDepartment of Surgery, University of Oklahoma Health Science Center, Oklahoma City, OK 73104, USA.
Ajay JainDepartment of Surgery, University of Oklahoma Health Science Center, Oklahoma City, OK 73104, USA.
Lacey R McNallyDepartment of Surgery, University of Oklahoma Health Science Center, Oklahoma City, OK 73104, USA.
University of Oklahoma Health Sciences Center · USUniversity of Oklahoma · US

Funding

Stroma Targeted Theranostic Nanoparticles for Pancreatic CancerR01CA212350 · NCI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI MCNALLY, LACEY R · 2017 to 2021
$1.7M
Theranostic Nanoparticles For Detection and Treatment of Pancreatic CancerR01EB020125 · NIBIB · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI MCNALLY, LACEY R · 2016 to 2019
$1.7M
Tumor-Specific Nanocontrast Agents for Improved Detection of Pancreatic CancerF31CA261044 · NCI · UNIVERSITY OF OKLAHOMA · PI MACCUAIG, WILLIAM · 2022 to 2023
$79k
NCI NIH HHS F31 CA261044NCI NIH HHS R01 CA212350NCI NIH HHS R01CA212350, F31CA261044NIBIB NIH HHS R01 EB020125
6 · The paper itself

Abstract

Image-guided nanotheranostics have the potential to represent a new paradigm in the treatment of cancer. Recent developments in modern imaging and nanoparticle design offer an answer to many of the issues associated with conventional chemotherapy, including their indiscriminate side effects and susceptibility to drug resistance. Imaging is one of the tools best poised to enable tailoring of cancer therapies. The field of image-guided nanotheranostics has the potential to harness the precision of modern imaging techniques and use this to direct, dictate, and follow site-specific drug delivery, all of which can be used to further tailor cancer therapies on both the individual and population level. The use of image-guided drug delivery has exploded in preclinical and clinical trials although the clinical translation is incipient. This review will focus on traditional mechanisms of targeted drug delivery in cancer, including the use of molecular targeting, as well as the foundations of designing nanotheranostics, with a focus on current clinical applications of nanotheranostics in cancer. A variety of specially engineered and targeted drug carriers, along with strategies of labeling nanoparticles to endow detectability in different imaging modalities will be reviewed. It will also introduce newer concepts of image-guided drug delivery, which may circumvent many of the issues seen with other techniques. Finally, we will review the current barriers to clinical translation of image-guided nanotheranostics and how these may be overcome.

Indexed as

antibody–drug conjugatesanticancer therapydrug carriersimage-guided therapynanoparticlesnanotheranosticsradiolabellingtargeted drug delivery

Identifiers

PMID35631503
PMCPMC9144228
OpenAlexW4224314011

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.