Evidence map›Paper›PMID 35631497›Full record

ArticlePharmaceutics2022

Bettina Quintanilha Magalhães, Francisco P Machado, Paola S Sanches, Bárbara Lima, Deborah Quintanilha Falcão, Natalia von Ranke, Murilo Lamim Bello, Carlos Rangel Rodrigues, Marcelo Guerra Santos, Leandro Rocha and 1 more

Open access · goldAbstract read
In one paragraph

Article in Pharmaceutics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Bettina Quintanilha MagalhãesLaboratório de Biotecnologia, Alimentação e Saúde, Universidade Federal Fluminense, R. Alexandre Moura, 8-São Domingos, Niterói 24210-200, Brazil.ORCID 0000-0001-8521-5171
Francisco P MachadoLaboratório de Tecnologia de Produtos Naturais, Faculdade de Farmácia, Universidade Federal Fluminense, Rua Doutor Mário Viana 523, Santa Rosa, Niterói 24241-000, Brazil.ORCID 0000-0002-5332-9972
Paola S SanchesLaboratório de Tecnologia de Produtos Naturais, Faculdade de Farmácia, Universidade Federal Fluminense, Rua Doutor Mário Viana 523, Santa Rosa, Niterói 24241-000, Brazil.
Bárbara LimaLaboratório de Tecnologia de Produtos Naturais, Faculdade de Farmácia, Universidade Federal Fluminense, Rua Doutor Mário Viana 523, Santa Rosa, Niterói 24241-000, Brazil.
Deborah Quintanilha FalcãoLaboratório de Tecnologia Farmacêutica I, Faculdade de Farmácia, Universidade Federal Fluminense, Rua Doutor Mário Viana 523, Santa Rosa, Niterói 24241-000, Brazil.
Natalia von RankeFaculdade de Farmácia, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, Brazil.
Murilo Lamim BelloFaculdade de Farmácia, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, Brazil.
Carlos Rangel RodriguesFaculdade de Farmácia, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, Brazil.
Marcelo Guerra SantosDepartamento de Ciências, Faculdade de Formação de Professores, Universidade do Estado do Rio de Janeiro, Francisco Portela 1470, São Gonçalo 24435-000, Brazil.
Leandro RochaLaboratório de Tecnologia de Produtos Naturais, Faculdade de Farmácia, Universidade Federal Fluminense, Rua Doutor Mário Viana 523, Santa Rosa, Niterói 24241-000, Brazil.ORCID 0000-0003-0484-1918
Robson X FariaLaboratório de Avaliação e Promoção da Saúde Ambiental, Instituto Oswaldo Cruz, Avenida Brasil 4365, Manguinhos, Rio de Janeiro 21040-900, Brazil.ORCID 0000-0001-8218-834X
Universidade Federal do Rio de Janeiro · BRUniversidade Federal Fluminense · BRUniversidade do Estado do Rio de Janeiro · BR

Funding

Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro E-26/200.982/2021Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro E-26/203.246/2017Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro E-26/211.025/2019National Council for Scientific and Technological Development 308755/2018-9
6 · The paper itself

Abstract

P2X7R is a purinergic receptor with broad expression throughout the body, especially in immune system cells. P2X7R activation causes inflammatory mediators to release, including interleukin-1β (IL-1β), the processing and release of which are critically dependent on this ion channel activation. P2X7R's therapeutic potential augments the discovery of new antagonistic compounds. Thus, we investigated whether the

Indexed as

ATPcytokinesEugenia sulcataionic channelsMyrtaceaenanoemulsion

Identifiers

PMID35631497
PMCPMC9148016
OpenAlexW4224310957

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.