Evidence map›Paper›PMID 35631470›Full record

ReviewPharmaceuticals (Basel, Switzerland)2022

Microencapsulating Alginate-Based Polymers for Probiotics Delivery Systems and Their Application.

Xiaochen Wang, Shukun Gao, Shuaiting Yun, Mingjing Zhang, Liyang Peng, Yingxiu Li, Yanxia Zhou

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Pharmaceuticals (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

61 citing papers in PubMed, 1 synthesis or guideline pooled it.

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1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Xiaochen WangMarine College, Shandong University, Weihai 264209, China.
Shukun GaoMarine College, Shandong University, Weihai 264209, China.
Shuaiting YunMarine College, Shandong University, Weihai 264209, China.
Mingjing ZhangMarine College, Shandong University, Weihai 264209, China.
Liyang PengMarine College, Shandong University, Weihai 264209, China.
Yingxiu LiMarine College, Shandong University, Weihai 264209, China.
Yanxia ZhouMarine College, Shandong University, Weihai 264209, China.ORCID 0000-0003-0393-8136

Funding

National Natural Science Foundation of China 31700116Natural Science Foundation of Shandong Province ZR2017MC019
6 · The paper itself

Abstract

Probiotics exhibit many health benefits and a great potential for broad applications in pharmaceutical fields, such as prevention and treatment of gastrointestinal tract diseases (irritable bowel syndrome), prevention and therapy of allergies, certain anticancer effects, and immunomodulation. However, their applications are limited by the low viability and metabolic activity of the probiotics during processing, storage, and delivery in the digestive tract. To overcome the mentioned limitations, probiotic delivery systems have attracted much attention. This review focuses on alginate as a preferred polymer and presents recent advances in alginate-based polymers for probiotic delivery systems. We highlight several alginate-based delivery systems containing various types of probiotics and the physical and chemical modifications with chitosan, cellulose, starch, protein, fish gel, and many other materials to enhance their performance, of which the viability and protective mechanisms are discussed. Withal, various challenges in alginate-based polymers for probiotics delivery systems are traced out, and future directions, specifically on the use of nanomaterials as well as prebiotics, are delineated to further facilitate subsequent researchers in selecting more favorable materials and technology for probiotic delivery.

Indexed as

alginatechemically modifiedmicroencapsulatephysically modifiedprobiotic

Identifiers

PMID35631470
PMCPMC9144165

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.