Evidence map›Paper›PMID 35631314›Full record

ArticleNutrients2022

Handgrip Strength Values Depend on Tumor Entity and Predict 180-Day Mortality in Malnourished Cancer Patients.

Pascal Tribolet, Nina Kaegi-Braun, Carla Gressies, Annic Baumgartner, Karl-Heinz Wagner, Zeno Stanga, Philipp Schuetz

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrients, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06260111 (Laser Photobiomodulation to Prevent Oral Mucositis and Functional Impairment Among Adult Hematologic Cancer Patients Undergoing Hematopoietic Stem Cell Transplantation), which is not on this map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06260111 naunknown statusnot on this mapstarted 2024, after this paper: background citation

Laser Photobiomodulation to Prevent Oral Mucositis and Functional Impairment Among Adult Hematologic Cancer Patients Undergoing Hematopoietic Stem Cell Transplantation

TypeinterventionalSponsorUniversidad del DesarrolloRan2024 to 2025Enrolled30ConditionsHematologic CancerArmsPhotobiomodulation, Usual care
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Physical function and symptoms in adult hematopoietic stem cell transplantation patients, by severity of oral mucositis: a prospective study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
    Article
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  6. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Pascal TriboletDepartment of Health Professions, Bern University of Applied Sciences, 3008 Bern, Switzerland.
Nina Kaegi-BraunDivision of General Internal and Emergency Medicine, Medical University Department, Kantonsspital Aarau, 5001 Aarau, Switzerland.ORCID 0000-0003-4015-295X
Carla GressiesDivision of General Internal and Emergency Medicine, Medical University Department, Kantonsspital Aarau, 5001 Aarau, Switzerland.
Annic BaumgartnerDivision of General Internal and Emergency Medicine, Medical University Department, Kantonsspital Aarau, 5001 Aarau, Switzerland.
Karl-Heinz WagnerDepartment of Nutritional Sciences and Research Platform Active Ageing, University of Vienna, 1090 Vienna, Austria.ORCID 0000-0002-1683-7265
Zeno StangaDivision of Diabetes, Endocrinology, Nutritional Medicine and Metabolism, Inselspital, Bern University Hospital, University of Bern, 4001 Bern, Switzerland.
Philipp SchuetzDivision of General Internal and Emergency Medicine, Medical University Department, Kantonsspital Aarau, 5001 Aarau, Switzerland.ORCID 0000-0001-6400-4949
Kantonsspital Aarau · CHUniversity of Vienna · ATUniversity of Basel · CHUniversity of Bern · CH

Funding

Research Council of the Kantonsspital Aarau, Switzerland 1410.000.058, 1410.000.044Swiss National Science Foundation PP00P3_150531, PP00P3_176972
6 · The paper itself

Abstract

backgroundCancer-related malnutrition is a prevalent condition associated with a loss of muscle mass and impaired functional status, leading to immunodeficiency, impaired quality of life and adverse clinical outcomes. Handgrip strength (HGS) is a practical measure to assess muscle strength in individual patients during clinical practice. However, HGS reference values refer to populations of healthy people, and population-specific values, such as those in the population of cancer patients, still need to be defined.

methodsWithin a secondary analysis of a previous randomized controlled nutritional trial focusing on hospitalized cancer patients at risk for malnutrition, we investigated sex-specific HGS values stratified by age and tumor entity. Additionally, we examined the association between HGS and 180-day all-cause mortality.

resultsWe included data from 628 cancer patients, which were collected from eight hospitals in Switzerland. Depending on the age of patients, HGS varied among female patients from 7 kg to 26 kg and among male patients from 20.5 kg to 44 kg. An incremental decrease in handgrip strength by 10 kg resulted in a 50% increase in 180-day all-cause mortality (odds ratio 1.52 (95%CI 1.19 to 1.94),

conclusionOur data provide evidence of the prognostic implications of HGS measurement in cancer patients and validate the prognostic value of handgrip strength in regard to long-term mortality. In addition, our results provide expected HGS values in the population of hospitalized malnourished cancer patients, which may allow better interpretation of values in individual patients.

Indexed as

MalnutritionNeoplasmsFemaleHand StrengthHumansMaleMuscle StrengthQuality of Lifecancerclinical outcomeshandgrip strengthmalnutritionnutritional support

Identifiers

PMID35631314
PMCPMC9146854
OpenAlexW4281399591

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.