ArticleNutrients2022
The Effects of "Diet-Smoking-Gender" Three-Way Interactions on Cognitive Impairment among Chinese Older Adults.
Article in Nutrients, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.
- Dietary diversity and cognitive performance in older adults: a systematic review.BMC neurology · 2025Pooled it
- Research on fall prediction in elderly patients with chronic diseases based on explainable machine learning: an aging perspective.BMC geriatrics · 2026Article
- Physical activities, longevity gene, and all-cause mortality among older adults: a prospective community-based cohort study.BMC medicine · 2025Article
- The mediating role of psychological equilibrium in the relationship between dietary variety and self-reported health among older adults in rural China.Scientific reports · 2025Article
- Integrated healthy lifestyle even in late-life mitigates cognitive decline risk across varied genetic susceptibility.Nature communications · 2025Article
- Exploring the association between vitamin D levels and dyslipidemia risk: insights from machine learning and generalized additive models.Frontiers in nutrition · 2025Article
- Effect of ferric citrate on hippocampal iron accumulation and widespread molecular alterations associated with cognitive disorder in an ovariectomized mice model.CNS neuroscience & therapeutics · 2024Article
- Article
- The Mediating Role of Psychological Balance on the Effects of Dietary Behavior on Cognitive Impairment in Chinese Elderly.Nutrients · 2024Article
- Decoding emotional resilience in aging: unveiling the interplay between daily functioning and emotional health.Frontiers in public health · 2024Article
- Prevalence, awareness, treatment, and control of dyslipidemia in Chinese adults: a systematic review and meta-analysis.Frontiers in cardiovascular medicine · 2023Review
- Age and cohort trends of the impact of socioeconomic status on dietary diversity among Chinese older adults from the perspective of urban-rural differences: A prospective cohort study based on CLHLS 2002-2018.Frontiers in nutrition · 2022Article
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Authors and funding
4 authors at 4 institutions in 3 countries.
Funding
Abstract
Investigations on gender variations in the risk factors of cognitive impairment are required to promote future precision medicine among older adults, as well as to contribute to a better understanding of the "male-female health-survival paradox". With this study, we aimed to investigate the effects of "diet-smoking-gender" three-way interactions on cognitive impairments among Chinese older adults. We conducted a 16-year prospective cohort study among 15,953, 15,555, 16,849, 9716, 7116, and 13,165 older adults from the 2002, 2005, 2008-2009, 2011-2012, 2014, and 2017-2018 waves of the Chinese Longitudinal Healthy Longevity Survey (CLHLS), respectively. Cognitive impairment was measured by the Mini-Mental State Examination (MMSE). The dietary diversity score (DDS) was calculated using the CLHLS food frequency questionnaire. Generalized estimating equations (GEE) were used to assess the "diet-smoking-gender" three-way interaction effects on cognitive impairment across the six waves of CLHLS. We found that higher dietary diversity was associated with lower probability of cognitive impairment among older adults (OR = 0.92; 95%CI = 0.90, 0.98). However, smoking behavior may negatively influence the protective effect of higher dietary diversity on cognitive function among females (OR = 1.26; 95%CI = 1.07, 1.49). Our findings imply that we should take gender differences and lifestyle behaviors into consideration in implementing dietary interventions to improve cognitive function among older adults.
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