Evidence map›Paper›PMID 35631263›Full record

Observational studyNutrients2022

Epigenetic Profiling in the Saliva of Obese Pregnant Women.

Chiara Mandò, Silvio Abati, Gaia Maria Anelli, Chiara Favero, Anaïs Serati, Laura Dioni, Marta Zambon, Benedetta Albetti, Valentina Bollati, Irene Cetin

Open access · goldAbstract readObservational Study
In one paragraph

Observational study in Nutrients, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 12 citations in OpenAlex.

  1. Impact of Maternal Immune Response on Oral Health and Pregnancy Outcomes.Advances in experimental medicine and biology · 2026
    Review
  2. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Chiara MandòDepartment of Biomedical and Clinical Sciences, Università degli Studi di Milano, 20157 Milan, Italy.ORCID 0000-0003-3458-3075
Silvio AbatiDepartment of Dentistry, University Vita-Salute San Raffaele, 20132 Milan, Italy.ORCID 0000-0002-3226-8242
Gaia Maria AnelliDepartment of Biomedical and Clinical Sciences, Università degli Studi di Milano, 20157 Milan, Italy.ORCID 0000-0002-3568-8971
Chiara FaveroEPIGET LAB, Department of Clinical Sciences and Community Health, Università degli Studi di Milano, 20122 Milan, Italy.
Anaïs SeratiDepartment of Biomedical and Clinical Sciences, Università degli Studi di Milano, 20157 Milan, Italy.ORCID 0000-0003-2247-0348
Laura DioniEPIGET LAB, Department of Clinical Sciences and Community Health, Università degli Studi di Milano, 20122 Milan, Italy.
Marta ZambonDepartment of Woman, Mother and Child, Luigi Sacco and Vittore Buzzi Children Hospital, ASST Fatebenefratelli-Sacco, 20154 Milan, Italy.
Benedetta AlbettiEPIGET LAB, Department of Clinical Sciences and Community Health, Università degli Studi di Milano, 20122 Milan, Italy.
Valentina BollatiEPIGET LAB, Department of Clinical Sciences and Community Health, Università degli Studi di Milano, 20122 Milan, Italy.ORCID 0000-0002-0370-9598
Irene CetinDepartment of Biomedical and Clinical Sciences, Università degli Studi di Milano, 20157 Milan, Italy.ORCID 0000-0002-9217-3034
University of Milan · ITASST Fatebenefratelli Sacco · ITVita-Salute San Raffaele University · IT

Funding

Italian Ministry of Health RF-2016-02362165Italian Ministry of University and Research 20102chst5_005
6 · The paper itself

Abstract

Maternal obesity is associated with inflammation and oxidative stress, strongly impacting the intrauterine environment with detrimental consequences for both mother and offspring. The saliva is a non-invasive biofluid reflecting both local and systemic health status. This observational study aimed to profile the epigenetic signature in the saliva of Obese (OB) and Normal-Weight (NW) pregnant women. Sixteen NW and sixteen OB Caucasian women with singleton spontaneous pregnancies were enrolled. microRNAs were quantified by the OpenArray Platform. The promoter region methylation of Suppressor of Cytokine Signaling 3 (

Indexed as

Epigenesis, GeneticMicroRNAsObesityPregnancy ComplicationsDNA MethylationFemaleHumansPregnancyPregnant PeoplePromoter Regions, GeneticSalivaSuppressor of Cytokine Signaling 3 ProteinTransforming Growth Factor beta1MicroRNAsSOCS3 protein, humanSuppressor of Cytokine Signaling 3 ProteinTGFB1 protein, humanTransforming Growth Factor beta1DNA methylationepigeneticsGDMinflammationmaternal obesitymiRNAoxidative stressperiodontal diseasepregnancysaliva

Identifiers

PMID35631263
PMCPMC9146705
OpenAlexW4280553205

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.