Evidence map›Paper›PMID 35631210›Full record

ArticleNutrients2022

Royal Jelly Protected against Dextran-Sulfate-Sodium-Induced Colitis by Improving the Colonic Mucosal Barrier and Gut Microbiota.

Jianying Guo, Baochen Ma, Zixu Wang, Yaoxing Chen, Wenli Tian, Yulan Dong

Open access · goldAbstract read
In one paragraph

Article in Nutrients, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
7.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 38 citations in OpenAlex.

  1. Article
  2. Review
  3. Journal of pain research · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. International journal of molecular sciences · 2025
    Article
  9. Frontiers in pharmacology · 2025
    Article
  10. Review
  11. The ethanolic extract of domesticatedFood science and biotechnology · 2024
    Article
  12. Article
  13. Royal Jelly: Biological Action and Health Benefits.International journal of molecular sciences · 2024
    Review
  14. Review
  15. Review
  16. Article
  17. Review
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Jianying GuoKey Laboratory of Precision Nutrition and Food Quality, Ministry of Education, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China.
Baochen MaChina Animal Husbandry Group, Beijing 100070, China.
Zixu WangKey Laboratory of Precision Nutrition and Food Quality, Ministry of Education, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China.
Yaoxing ChenKey Laboratory of Precision Nutrition and Food Quality, Ministry of Education, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China.ORCID 0000-0003-2576-5977
Wenli TianInstitute of Apicultural Research, Chinese Academy of Agricultural Sciences, Beijing 100093, China.
Yulan DongKey Laboratory of Precision Nutrition and Food Quality, Ministry of Education, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China.
China Agricultural University · CNChinese Academy of Agricultural Sciences · CNNational Animal Husbandry Service · CN

Funding

National Natural Science Foundation of Beijing 6172022,6212018National Natural Science Foundation of China 31972633, 31972087, 31572476, 31272483
6 · The paper itself

Abstract

Royal jelly (RJ) is a natural bee product that contains a variety of biologically active ingredients and has antitumor, antiallergic, antibacterial and immune-regulating effects. Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the intestine that can cause abdominal pain and diarrhea. With this study, we aimed to explore the protective effect of RJ on DSS-induced colitis in mice. The physiochemical parameters (water, protein, 10-hydroxy-2-decenoic acid, total sugar, starch, ash and acidity) of the RJ samples used in this study met the requirements of the international and Chinese national standards. Treatment with RJ improved symptoms and colonic cell apoptosis and decreased intestinal permeability by increasing the expression of tight-junction protein, goblet cells and their secretion mucin, MUC2, in DSS-induced ulcerative colitis mice. RJ also reduced the expression of proinflammatory cytokine IL-6 and increased the expression of anti-inflammatory cytokine IL-10 and sIgA. DSS resulted in an increase in the relative abundance of

Indexed as

ColitisFatty AcidsGastrointestinal MicrobiomeAnimalsBeesCytokinesDextran SulfateMiceRoyal JellySodiumCytokinesDextran SulfateFatty AcidsRoyal JellySodiumcolitisgut microbiotainflammatory bowel diseaseintestinal mucosal barrierroyal jelly

Identifiers

PMID35631210
PMCPMC9143990
OpenAlexW4280575153

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.