Evidence map›Paper›PMID 35631132›Full record

ArticleNutrients2022

Hypercoagulability Impairs Plaque Stability in Diabetes-Induced Atherosclerosis.

Saira Ambreen, Sameen Fatima, Ahmed Elwakiel, Rajiv Rana, Kunal Singh, Anubhuti Gupta, Dheerendra Gupta, Hamzah Khawaja, Jayakumar Manoharan, Christian Besler and 4 more

Open access · goldAbstract read
In one paragraph

Article in Nutrients, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.1field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Saira AmbreenInstitute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostic, University Hospital Leipzig, 04103 Leipzig, Germany.
Sameen FatimaInstitute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostic, University Hospital Leipzig, 04103 Leipzig, Germany.
Ahmed ElwakielInstitute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostic, University Hospital Leipzig, 04103 Leipzig, Germany.ORCID 0000-0001-6784-8370
Rajiv RanaInstitute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostic, University Hospital Leipzig, 04103 Leipzig, Germany.
Kunal SinghInstitute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostic, University Hospital Leipzig, 04103 Leipzig, Germany.
Anubhuti GuptaInstitute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostic, University Hospital Leipzig, 04103 Leipzig, Germany.
Dheerendra GuptaInstitute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostic, University Hospital Leipzig, 04103 Leipzig, Germany.
Hamzah KhawajaInstitute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostic, University Hospital Leipzig, 04103 Leipzig, Germany.
Jayakumar ManoharanInstitute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostic, University Hospital Leipzig, 04103 Leipzig, Germany.ORCID 0000-0001-9435-4085
Christian BeslerCardiology, Leipzig Heart Center, University of Leipzig, 04289 Leipzig, Germany.ORCID 0000-0002-8082-6472
Ulrich LaufsKlinik und Poliklinik für Kardiologie, University Hospital Leipzig, 04103 Leipzig, Germany.ORCID 0000-0003-2620-9323
Shrey KohliInstitute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostic, University Hospital Leipzig, 04103 Leipzig, Germany.ORCID 0000-0003-2118-7380
Berend IsermannInstitute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostic, University Hospital Leipzig, 04103 Leipzig, Germany.ORCID 0000-0003-0714-6160
Khurrum ShahzadInstitute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostic, University Hospital Leipzig, 04103 Leipzig, Germany.ORCID 0000-0001-7217-2221
University Hospital Leipzig · DELeipzig Heart Institute · DE

Funding

Deutsche Forschungsgemeinschaft 236360313/SFB 1118Deutsche Forschungsgemeinschaft 361210922/GRK2408/P5Deutsche Forschungsgemeinschaft 361210922/GRK2408/P7&P9Deutsche Forschungsgemeinschaft CRC854/B26Deutsche Forschungsgemeinschaft IS-67/11-1Deutsche Forschungsgemeinschaft IS 67/16-1Deutsche Forschungsgemeinschaft IS-67/22-1Deutsche Forschungsgemeinschaft IS-67/8-1Deutsche Forschungsgemeinschaft SH849/1-2Deutsche Forschungsgemeinschaft SH849/4-1
6 · The paper itself

Abstract

Diabetes mellitus, which is largely driven by nutritional and behavioral factors, is characterized by accelerated atherosclerosis with impaired plaque stability. Atherosclerosis and associated complications are the major cause of mortality in diabetic patients. Efficient therapeutic concepts for diabetes-associated atherosclerosis are lacking. Atherosclerosis among diabetic patients is associated with reduced endothelial thrombomodulin (TM) expression and impaired activated protein C (aPC) generation. Here, we demonstrate that atherosclerotic plaque stability is reduced in hyperglycemic mice expressing dysfunctional TM (TM

Indexed as

AtherosclerosisDiabetes MellitusPlaque, AtheroscleroticThrombophiliaAnimalsHumansMiceMice, Knockout, ApoEMyocytes, Smooth Muscleactivated protein Catherosclerosisdiabeteshypercoagulabilitymacrophagessmooth muscle cells

Identifiers

PMID35631132
PMCPMC9143009
OpenAlexW4280625089

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.