Evidence map›Paper›PMID 35631090›Full record

ReviewPathogens (Basel, Switzerland)2022

Challenges in Serologic Diagnostics of Neglected Human Systemic Mycoses: An Overview on Characterization of New Targets.

Moisés Morais Inácio, Vanessa Rafaela Milhomem Cruz-Leite, André Luís Elias Moreira, Karine Mattos, Juliano Domiraci Paccez, Orville Hernandez Ruiz, James Venturini, Marcia de Souza Carvalho Melhem, Anamaria Mello Miranda Paniago, Célia Maria de Almeida Soares and 2 more

Open access · goldAbstract readReview
In one paragraph

Review in Pathogens (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Moisés Morais InácioLaboratory of Molecular Biology, Institute of Biological Sciences, Federal University of Goiás, Goiânia 74690-900, Brazil.
Vanessa Rafaela Milhomem Cruz-LeiteLaboratory of Molecular Biology, Institute of Biological Sciences, Federal University of Goiás, Goiânia 74690-900, Brazil.
André Luís Elias MoreiraLaboratory of Molecular Biology, Institute of Biological Sciences, Federal University of Goiás, Goiânia 74690-900, Brazil.
Karine MattosFaculty of Medicine, Federal University of Mato Grosso do Sul, Campo Grande 79070-900, Brazil.ORCID 0000-0003-1177-2092
Juliano Domiraci PaccezLaboratory of Molecular Biology, Institute of Biological Sciences, Federal University of Goiás, Goiânia 74690-900, Brazil.ORCID 0000-0002-1086-4588
Orville Hernandez RuizMICROBA Research Group-Cellular and Molecular Biology Unit-CIB, School of Microbiology, University of Antioquia, Medellín 050010, Colombia.
James VenturiniFaculty of Medicine, Federal University of Mato Grosso do Sul, Campo Grande 79070-900, Brazil.
Marcia de Souza Carvalho MelhemFaculty of Medicine, Federal University of Mato Grosso do Sul, Campo Grande 79070-900, Brazil.
Anamaria Mello Miranda PaniagoBioscience Laboratory, Faculty of Pharmaceutical Sciences, Food and Nutrition, Federal University of Mato Grosso do Sul, Campo Grande 79070-900, Brazil.ORCID 0000-0002-8925-7712
Célia Maria de Almeida SoaresLaboratory of Molecular Biology, Institute of Biological Sciences, Federal University of Goiás, Goiânia 74690-900, Brazil.ORCID 0000-0001-5378-9840
Simone Schneider WeberBioscience Laboratory, Faculty of Pharmaceutical Sciences, Food and Nutrition, Federal University of Mato Grosso do Sul, Campo Grande 79070-900, Brazil.ORCID 0000-0002-4181-142X
Clayton Luiz BorgesLaboratory of Molecular Biology, Institute of Biological Sciences, Federal University of Goiás, Goiânia 74690-900, Brazil.ORCID 0000-0002-9914-8771
Universidade Federal de Goiás · BRUniversidade Federal de Mato Grosso do Sul · BRFundação de Apoio a Pesquisa do Estado de Goiás · BRUniversidad de Antioquia · CO

Funding

Coordenação de Aperfeicoamento de Pessoal de Nível Superior 88882.458447/2019-01Fundação de Apoio a Pesquisa do Estado de Goiás INCT-IPH
6 · The paper itself

Abstract

Systemic mycoses have been viewed as neglected diseases and they are responsible for deaths and disabilities around the world. Rapid, low-cost, simple, highly-specific and sensitive diagnostic tests are critical components of patient care, disease control and active surveillance. However, the diagnosis of fungal infections represents a great challenge because of the decline in the expertise needed for identifying fungi, and a reduced number of instruments and assays specific to fungal identification. Unfortunately, time of diagnosis is one of the most important risk factors for mortality rates from many of the systemic mycoses. In addition, phenotypic and biochemical identification methods are often time-consuming, which has created an increasing demand for new methods of fungal identification. In this review, we discuss the current context of the diagnosis of the main systemic mycoses and propose alternative approaches for the identification of new targets for fungal pathogens, which can help in the development of new diagnostic tests.

Indexed as

diagnosisexperimental approachesin silico approachesnew targetssystemic mycoses

Identifiers

PMID35631090
PMCPMC9143782
OpenAlexW4280618783

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.