ArticleNanomaterials (Basel, Switzerland)2022
The Biological Effects of Polystyrene Nanoplastics on Human Peripheral Blood Lymphocytes.
Article in Nanomaterials (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 61 citations in OpenAlex.
- Histopathological, Biochemical and Molecular Investigations on the Potential Endocrine Disruption of Polystyrene Nanoparticles in Adult Male Albino Rats.Environmental toxicology · 2026Article
- Current Evidence Linking Microplastic Exposure and Reproductive Cancers.Journal of xenobiotics · 2026Review
- Ferroptosis and Wnt/β-Catenin Signaling Triggered by Environmentally Relevant Nanoscale Polypropylene Plastics in Human Intestinal Models.ACS environmental Au · 2026Article
- Nanoplastics impair antitumor NK and CD8⁺ T cell cytotoxicity and antiviral B cell antibody responses to SARS-CoV-2.Scientific reports · 2026Article
- Article
- Nanoplastic toxicity and uptake in kidney cells: differential effects of concentration, particle size, and polymer type.Cell biology and toxicology · 2026Article
- Pathways, Mechanisms, and Therapeutic Strategies of Neurotoxicity Induced by Micro- and Nanoplastics.Brain sciences · 2025Review
- Review
- Micro-nanoplastic induced cardiovascular disease and dysfunction: a scoping review.Journal of exposure science & environmental epidemiology · 2025Article
- Article
- Review of mechanisms and impacts of nanoplastic toxicity in aquatic organisms and potential impacts on human health.Toxicology reports · 2025Review
- Nanoplastics: Immune Impact, Detection, and Internalization after Human Blood Exposure by Single-Cell Mass Cytometry.Advanced materials (Deerfield Beach, Fla.) · 2025Article
- Article
- Unmasking the Invisible Threat: Biological Impacts and Mechanisms of Polystyrene Nanoplastics on Cells.Toxics · 2024Review
- Impact of micro-nano plastics in daily life on human health: toxicological evaluation from the perspective of normal tissue cells and organoids.Toxicology research · 2024Review
- Molecular and Cellular Effects of Microplastics and Nanoplastics: Focus on Inflammation and Senescence.Cells · 2024Review
- In Vitro and In Vivo Genotoxicity of Polystyrene Microplastics: Evaluation of a Possible Synergistic Action with Bisphenol A.Journal of xenobiotics · 2024Article
- Degradation of Polymer Materials in the Environment and Its Impact on the Health of Experimental Animals: A Review.Polymers · 2024Review
- Identification and quantification of micro-nano-plastics in polypropylene-bottled injections.Heliyon · 2024Article
- Interfacial Interactions between Nanoplastics and Biological Systems: toward an Atomic and Molecular Understanding of Plastics-Driven Biological Dyshomeostasis.ACS applied materials & interfaces · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Environmental exposure to microplastics (MPs) and nanoplastics (NPs) is an increasing concern from human health perspectives. Little information on the genotoxic and cytotoxic potential of NP particles in human cells is available. We aimed to assess the cytotoxic and genotoxic potential of polystyrene nanoplastics (PSNPs) at different concentrations (2000μg/mL, 1000μg/mL, and 500μg/mL) by using chromosomal aberration (CA) and cytokinesis-block micronucleus assays (CBMN) on human peripheral lymphocytes. Dose-dependent hemolytic activity and cell viability were observed against the PSNPs exposure. Increased chromosomal aberrations, such as chromosomal breaks and dicentric chromosomes, and an increase in nucleoplasmic bridge (NBP) formation and nuclear budding (NBUD) were observed. The frequency of mitotic index (MI) decreased significantly in the PSNP-exposed groups from lower to higher concentrations. A significant increase in micronuclei (MN) formation and cytostasis% and a dose-dependent reduction in nuclear division index (NDI) in PSNP-exposed groups indicated oxidative stress-mediated cytotoxicity, DNA damage, and genomic instabilities due to PSNP exposure in human lymphocyte cells. This study highlights the importance of understanding the toxic mechanisms and associated chronic and acute health effects on humans due to exposure to this pervasive environmental pollutant.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.