Evidence map›Paper›PMID 35630755›Full record

ArticleMolecules (Basel, Switzerland)2022

Spectroscopic Characterization of 3-Aminoisoxazole, a Prebiotic Precursor of Ribonucleotides.

Alessio Melli, Mattia Melosso, Kevin G Lengsfeld, Luca Bizzocchi, Víctor M Rivilla, Luca Dore, Vincenzo Barone, Jens-Uwe Grabow, Cristina Puzzarini

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Alessio MelliScuola Normale Superiore, Piazza dei Cavalieri 7, 56126 Pisa, Italy.ORCID 0000-0002-8469-1624
Mattia MelossoScuola Superiore Meridionale, Università di Napoli Federico II, Largo San Marcellino 10, 80138 Naples, Italy.
Kevin G LengsfeldInstitut für Physikalische Chemie und Elektrochemie, Gottfried Wilhelm Leibniz Universität Hannover, Callinstraße 3A, 30167 Hannover, Germany.
Luca BizzocchiDipartimento di Chimica "Giacomo Ciamician", Università di Bologna, Via F. Selmi 2, 40126 Bologna, Italy.ORCID 0000-0002-9953-8593
Víctor M RivillaCentro de Astrobiología (CSIC-INTA), Ctra. de Ajalvir Km. 4, Torrejón de Ardoz, 28850 Madrid, Spain.
Luca DoreDipartimento di Chimica "Giacomo Ciamician", Università di Bologna, Via F. Selmi 2, 40126 Bologna, Italy.
Vincenzo BaroneScuola Normale Superiore, Piazza dei Cavalieri 7, 56126 Pisa, Italy.ORCID 0000-0001-6420-4107
Jens-Uwe GrabowInstitut für Physikalische Chemie und Elektrochemie, Gottfried Wilhelm Leibniz Universität Hannover, Callinstraße 3A, 30167 Hannover, Germany.ORCID 0000-0002-2663-8091
Cristina PuzzariniDipartimento di Chimica "Giacomo Ciamician", Università di Bologna, Via F. Selmi 2, 40126 Bologna, Italy.ORCID 0000-0002-2395-8532

Funding

Comunidad de Madrid 2019-T1/TIC-15379Deutsche Forschungsgemeinschaft GR1344/4-1..3Ministry of Education, Universities and Research 202082CE3T
6 · The paper itself

Abstract

The processes and reactions that led to the formation of the first biomolecules on Earth play a key role in the highly debated theme of the origin of life. Whether the first chemical building blocks were generated on Earth (endogenous synthesis) or brought from space (exogenous delivery) is still unanswered. The detection of complex organic molecules in the interstellar medium provides valuable support to the latter hypothesis. To gather more insight, here we provide the astronomers with accurate rotational frequencies to guide the interstellar search of 3-aminoisoxazole, which has been recently envisaged as a key reactive species in the scenario of the so-called RNA-world hypothesis. Relying on an accurate computational characterization, we were able to register and analyze the rotational spectrum of 3-aminoisoxazole in the 6-24 GHz and 80-320 GHz frequency ranges for the first time, exploiting a Fourier-transform microwave spectrometer and a frequency-modulated millimeter/sub-millimeter spectrometer, respectively. Due to the inversion motion of the -NH

Indexed as

RibonucleotidesEarth, PlanetMicrowavesSpectrum AnalysisRibonucleotidesastrochemistrylarge amplitude motionorigin of lifeprebiotic moleculesrotational spectroscopy

Identifiers

PMID35630755
PMCPMC9147597

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.