Evidence map›Paper›PMID 35630705›Full record

ArticleMolecules (Basel, Switzerland)2022

Synthesis of Mixed Dinucleotides by Mechanochemistry.

Faisal Hayat, Mikhail V Makarov, Luxene Belfleur, Marie E Migaud

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Faisal HayatMitchell Cancer Institute, Department of Pharmacology, College of Medicine, University of South Alabama, 1660 Springhill Avenue, Mobile, AL 36604, USA.ORCID 0000-0001-5493-0199
Mikhail V MakarovMitchell Cancer Institute, Department of Pharmacology, College of Medicine, University of South Alabama, 1660 Springhill Avenue, Mobile, AL 36604, USA.
Luxene BelfleurMitchell Cancer Institute, Department of Pharmacology, College of Medicine, University of South Alabama, 1660 Springhill Avenue, Mobile, AL 36604, USA.
Marie E MigaudMitchell Cancer Institute, Department of Pharmacology, College of Medicine, University of South Alabama, 1660 Springhill Avenue, Mobile, AL 36604, USA.
USA Mitchell Cancer Institute · US

Funding

Elysium Health N/ANIH HHS R21-AT009908
6 · The paper itself

Abstract

We report the synthesis of vitamin B1, B2, and B3 derived nucleotides and dinucleotides generated either through mechanochemical or solution phase chemistry. Under the explored conditions, adenosine and thiamine proved to be particularly amenable to milling conditions. Following optimization of the chemistry related to the formation pyrophosphate bonds, mixed dinucleotides of adenine and thiamine (vitamin B1), riboflavin (vitamin B2), nicotinamide riboside and 3-carboxamide 4-pyridone riboside (both vitamin B3 derivatives) were generated in good yields. Furthermore, we report an efficient synthesis of the MW+4 isotopologue of NAD

Indexed as

NiacinRiboflavinThiamineNiacinRiboflavinThiaminedinucleotidesmechanochemistrynicotinamidenucleotidespyrophosphatesriboflavinthiamine

Identifiers

PMID35630705
PMCPMC9147584
OpenAlexW4280516338

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.