Evidence map›Paper›PMID 35630694›Full record

ArticleMolecules (Basel, Switzerland)2022

Cationic Geminoid Peptide Amphiphiles Inhibit DENV2 Protease, Furin, and Viral Replication.

Mark Damen, Mario A Izidoro, Debora N Okamoto, Lilian C G Oliveira, Helene I V Amatdjais-Groenen, Stijn F M van Dongen, Koen W R van Cleef, Ronald P van Rij, Cindy E J Dieteren, Daniel Gironés and 6 more

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 3 countries.

Mark DamenDepartment of Organic Chemistry, Institute for Molecules and Materials, Faculty of Science, Radboud University, Heyendaalseweg 135, 6525 AJ Nijmegen, The Netherlands.
Mario A IzidoroDepartment of Biophysics, Escola Paulista de Medicina, Universidade Federal de São Paulo (UNIFESP), Rua Três de Maio, 100, São Paulo 04044-020, Brazil.
Debora N OkamotoDepartment of Biophysics, Escola Paulista de Medicina, Universidade Federal de São Paulo (UNIFESP), Rua Três de Maio, 100, São Paulo 04044-020, Brazil.
Lilian C G OliveiraDepartment of Biophysics, Escola Paulista de Medicina, Universidade Federal de São Paulo (UNIFESP), Rua Três de Maio, 100, São Paulo 04044-020, Brazil.ORCID 0000-0001-5117-6979
Helene I V Amatdjais-GroenenDepartment of Organic Chemistry, Institute for Molecules and Materials, Faculty of Science, Radboud University, Heyendaalseweg 135, 6525 AJ Nijmegen, The Netherlands.
Stijn F M van DongenDepartment of Organic Chemistry, Institute for Molecules and Materials, Faculty of Science, Radboud University, Heyendaalseweg 135, 6525 AJ Nijmegen, The Netherlands.
Koen W R van CleefDepartment of Medical Microbiology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Centre, 6500 HB Nijmegen, The Netherlands.
Ronald P van RijDepartment of Medical Microbiology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Centre, 6500 HB Nijmegen, The Netherlands.ORCID 0000-0003-0221-4689
Cindy E J DieterenProtinhi Therapeutics, Transistorweg 5, 6534 AT Nijmegen, The Netherlands.
Daniel GironésProtinhi Therapeutics, Transistorweg 5, 6534 AT Nijmegen, The Netherlands.
Bernd N M van BuurenProtinhi Therapeutics, Transistorweg 5, 6534 AT Nijmegen, The Netherlands.
Byron E E MartinaDepartment of Viroscience, Erasmus Medical Centre, 3015 GD Rotterdam, The Netherlands.
Albert D M E OsterhausArtemis Bio-Support, Molengraaffsingel 10, 2629 JD Delft, The Netherlands.ORCID 0000-0001-6535-3497
Luiz JulianoDepartment of Biophysics, Escola Paulista de Medicina, Universidade Federal de São Paulo (UNIFESP), Rua Três de Maio, 100, São Paulo 04044-020, Brazil.ORCID 0000-0002-5589-2822
Bob J ScholteDepartment of Cell Biology, Erasmus Medical Centre, 3000 CA Rotterdam, The Netherlands.
Martin C FeitersDepartment of Organic Chemistry, Institute for Molecules and Materials, Faculty of Science, Radboud University, Heyendaalseweg 135, 6525 AJ Nijmegen, The Netherlands.
Radboud University Nijmegen · NLUniversidade Federal de São Paulo · BRErasmus University Rotterdam · NLColsan - Associação Beneficente de Coleta de Sangue · BRUniversity of Veterinary Medicine Hannover, Foundation · DE

Funding

Brazilian research agencies FAPESP-Project 12/50191-4RConselho Nacional de Desenvolvimento Científico e Tecnológico CNPq-Projects 471340/2011-1 and 470388/2010-2Dutch Technology Foundation STW nac.6565European 6th Framework program LSHB-CT-2004-005213European Union/provinces of Gelderland and Overijssel EFRO Tropinhi, PROJ-00672Netherlands Organisation for Scientific Research NWO-NGO PreSeed grant 9363001
6 · The paper itself

Abstract

Dengue is an important arboviral infectious disease for which there is currently no specific cure. We report gemini-like (geminoid) alkylated amphiphilic peptides containing lysines in combination with glycines or alanines (C

Indexed as

Antiviral AgentsDengue VirusFurinProtease InhibitorsVirus ReplicationDengueHumansPeptide HydrolasesPeptidesViral Nonstructural ProteinsAntiviral AgentsFurinPeptide HydrolasesPeptidesProtease InhibitorsViral Nonstructural Proteinsamphiphilesdrug discoveryinhibitorsmembrane proteinspeptides

Identifiers

PMID35630694
PMCPMC9143577
OpenAlexW4280588803

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.