Evidence map›Paper›PMID 35630592›Full record

ArticleMolecules (Basel, Switzerland)2022

Novel Hybrid Benzoazacrown Ligand as a Chelator for Copper and Lead Cations: What Difference Does Pyridine Make.

Bayirta V Egorova, Lyubov S Zamurueva, Anastasia D Zubenko, Anna V Pashanova, Artem A Mitrofanov, Anna B Priselkova, Yuri V Fedorov, Alexander L Trigub, Olga A Fedorova, Stepan N Kalmykov

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 59% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. EJNMMI radiopharmacy and chemistry · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Bayirta V EgorovaChemistry Department, Lomonosov Moscow State University, Leninskie Gory, 1, 119991 Moscow, Russia.ORCID 0000-0002-2927-7359
Lyubov S ZamuruevaChemistry Department, Lomonosov Moscow State University, Leninskie Gory, 1, 119991 Moscow, Russia.
Anastasia D ZubenkoA. N. Nesmeyanov Institute of Organoelement Compounds of the Russian Academy of Sciences, Vavilova, 28, GSP-1, 119991 Moscow, Russia.ORCID 0000-0003-4707-3875
Anna V PashanovaA. N. Nesmeyanov Institute of Organoelement Compounds of the Russian Academy of Sciences, Vavilova, 28, GSP-1, 119991 Moscow, Russia.
Artem A MitrofanovChemistry Department, Lomonosov Moscow State University, Leninskie Gory, 1, 119991 Moscow, Russia.ORCID 0000-0001-8891-6862
Anna B PriselkovaSkobeltsyn Institute of Nuclear Physics, Lomonosov Moscow State University, Leninskie Gory, 1, 119991 Moscow, Russia.
Yuri V FedorovA. N. Nesmeyanov Institute of Organoelement Compounds of the Russian Academy of Sciences, Vavilova, 28, GSP-1, 119991 Moscow, Russia.
Alexander L TrigubNational Research Center "Kurchatov Institute", Akademika Kurchatova Sqr., 1, 123098 Moscow, Russia.
Olga A FedorovaA. N. Nesmeyanov Institute of Organoelement Compounds of the Russian Academy of Sciences, Vavilova, 28, GSP-1, 119991 Moscow, Russia.
Stepan N KalmykovChemistry Department, Lomonosov Moscow State University, Leninskie Gory, 1, 119991 Moscow, Russia.
Lomonosov Moscow State University · RUA. N. Nesmeyanov Institute of Organoelement Compounds · RUD. Mendeleyev University of Chemical Technology of Russia · RUKurchatov Institute · RU

Funding

Russian Science Foundation 18-73-10035
6 · The paper itself

Abstract

A synthetic procedure for the synthesis of azacrown ethers with a combination of pendant arms has been developed and the synthesized ligand, characterized by various techniques, was studied. The prepared benzoazacrown ether with hybrid pendant arms and its complexes with copper and lead cations were studied in terms of biomedical applications. Similarly to a fully acetate analog, the new one binds both cations with close stability constants, despite the decrease in both constants. The calculated geometry of the complexes correlate with the data from X-ray absorption and NMR spectroscopy. Coordination of both cations differs due to the difference between the ionic radii. However, these chelation modes provide effective shielding of cations in both cases, that was shown by the stability of their complexes in the biologically relevant media towards transchelation and transmetallation.

Indexed as

Chelating AgentsCopperCationsLigandsPyridinesCationsChelating AgentsCopperLigandsPyridinesazacrown ethercopper-64lead-212list three to tenradiopharmaceuticalstability of complexes

Identifiers

PMID35630592
PMCPMC9143346
OpenAlexW4280642516

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.